Matrix metalloproteinase 9 in mucosally invasive gastric cancer.
Matrix metalloproteinase 9 in mucosally invasive gastric cancer.
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DOI：
10.1007/s101200050008
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发表时间：
1998-03-01
期刊：
影响因子：
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通讯作者：
Kito, Tsuyoshi
中科院分区：
文献类型：
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作者：
Torii, Akihito;Kodera, Yasuhiro;Kito, Tsuyoshi
背景：基质金属蛋白酶9 （MMP-9）通过基底膜降解促进肿瘤的侵袭和转移。在这些过程中，已经观察到癌症基质细胞相互作用对MMP-9产生的控制。方法：我们使用一步夹心酶免疫分析法测量血浆MMP-9浓度，并在局限于粘膜的小胃癌患者中使用免疫组织化学方法定位MMP-9。根据国际抗癌联盟的肿瘤-淋巴结-转移（TNM）分类，将肿瘤分为上皮内肿瘤（Tis）和T1疾病。结果：T1疾病患者MMP-9的阳性率和平均值高于Tis疾病患者。在T1肿瘤中，免疫组织化学测定的MMP-9表达在癌间质细胞中高于非癌间质细胞，这种情况仅在少数Tis肿瘤中发现。结论：这些结果提示MMP-9与胃癌侵袭的第一步有关。
BACKGROUND: Matrix metalloproteinase 9 (MMP-9) facilitates tumor invasion and metastasis via basement membrane degradation. Control of MMP-9 production by cancer-stromal cell interactions in these processes has been observed.METHODS: We measured plasma MMP-9 concentrations, using a one-step sandwich enzyme immunoassay, and also immunohistochemically localized MMP-9 in patients with small gastric cancers limited to the mucosa. The cancers were classified as intraepithelial tumor (Tis) and T1 disease according to the tumor-node-metastasis (TNM) classification of the International Union Against Cancer.RESULTS: Patients with T1 disease had a higher positivity rate for and mean value of MMP-9 than patients with Tis disease. In T1 tumors, MMP-9 expression determined immunohistochemically, was greater in cells in cancer stroma than in cells in noncancerous stroma, a situation found in only a few Tis tumors.CONCLUSIONS: These results suggest that MMP-9 is related to the initial step of gastric cancer invasion.