Chemically modified cellulose fibrous meshes for use as tissue engineering scaffolds
Chemically modified cellulose fibrous meshes for use as tissue engineering scaffolds
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DOI：
10.1016/j.bmcl.2011.04.032
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发表时间：
2011-09-01
影响因子：
2.7
通讯作者：
Song, Jie
中科院分区：
文献类型：
--
作者：
Filion, Tera M.;Kutikov, Artem;Song, Jie
采用静电纺丝、热机械退火和化学改性相结合的方法制备了在水中具有坚固结构和机械完整性的纤维素和硫酸盐纤维素纤维网。与纤维素网相比，硫酸盐纤维网对重组骨形态发生蛋白-2的保留能力更高，保留的蛋白至少保持7天的生物活性。在缺乏成骨生长因子的情况下，硫酸盐纤维网也更容易支持大鼠骨髓基质细胞的附着和成骨分化。这些特性使硫酸盐纤维素纤维网成为一种很有前途的骨组织工程支架。(c) 2011 Elsevier Ltd.版权所有。
Cellulose and sulfated cellulose fibrous meshes exhibiting robust structural and mechanical integrity in water were fabricated using a combination of electrospinning, thermal-mechanical annealing and chemical modifications. The sulfated fibrous mesh exhibited higher retention capacity for human recombinant bone morphogenetic protein-2 than the cellulose mesh, and the retained proteins remained biologically active for at least 7 days. The sulfated fibrous mesh also more readily supported the attachment and osteogenic differentiation of rat bone marrow stromal cells in the absence of osteogenic growth factors. These properties combined make the sulfated cellulose fibrous mesh a promising bone tissue engineering scaffold. (c) 2011 Elsevier Ltd. All rights reserved.