Antigenic variation between Newcastle disease viruses of goose and chicken origin
Antigenic variation between Newcastle disease viruses of goose and chicken origin
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鹅源和鸡源新城疫病毒之间的抗原变异
DOI：
10.1007/s00705-010-0610-7
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发表时间：
2010-04-01
影响因子：
2.7
通讯作者：
Cong, Yan-long
中科院分区：
文献类型：
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作者：
Li, Zhi-jie;Li, Yang;Cong, Yan-long
新城疫病毒（NDV）被认为仅感染家养鸟类，而鹅等水禽要么未被感染，即使被强毒株感染，要么仅发生隐性感染。 20世纪90年代末以来，我国多个省份暴发了一种高发病率、高死亡率的鹅群新传染病。这种疾病是由 I 型禽副粘病毒（APMV-1）—NDV 引起的。为了研究NDV如何在鸡和鹅之间传播，通过体内和体外交叉中和测定评估了NDV毒株（鹅源NDV/NA-1和鸡源NDV/F48E9、F48E8）的血清学相似性。结果表明NDV/NA-1株与NDV/F48E9、F48E8株之间发生了抗原变异。值得注意的是，与 F48E9 疫苗接种的禽类相比，NDV/NA-1 有效保护疫苗接种的禽类免受 NDV/NA-1 毒株攻击的发病率和死亡率，并且显着减少了疫苗接种禽类的病毒脱落。这可能为鹅NDV的进化提供线索。
Newcastle disease virus (NDV) is believed to infect only domestic avian species, with waterfowl such as geese either not being infected, even by virulent strains, or developing only inapparent infection. Since the late 1990s, a new infectious disease producing high morbidity and mortality among geese broke out in many provinces of China. This disease was caused by a serotype I avian paramyxovirus known as (APMV-1)—NDV. To investigate how NDV spreads between chickens and geese, the serological similarities of NDV strains (goose-origin NDV/NA-1 and chicken-origin NDV/F48E9, F48E8) were assessed by cross-neutralization assays both in vivo and in vitro. The results indicated that antigenic variation had occurred between NDV/NA-1 strains and NDV/F48E9, F48E8 strains. Notably, NDV/NA-1 effectively protected vaccinated birds from morbidity and mortality against NDV/NA-1 strain challenge and significantly reduced virus shedding from the vaccinated birds when compared with F48E9-vaccinated birds. This might provide clues to the evolution of the goose NDV.