Itching sensation in psoriatic patients and its relation to body mass index and IL-17 and IL-31 concentrations
Itching sensation in psoriatic patients and its relation to body mass index and IL-17 and IL-31 concentrations
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DOI：
10.5114/pdia.2015.56097
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发表时间：
2015-01-01
影响因子：
1.4
通讯作者：
Jenerowicz, Dorota
中科院分区：
文献类型：
--
作者：
Czarnecka-Operacz, Magdalena;Polanska, Adriana;Jenerowicz, Dorota
导读：根据现有资料，瘙痒是银屑病的常见症状，但其特点和发病机制尚不清楚。目的：本研究的主要目的是评估牛皮癣患者的瘙痒感觉，包括其发病率和严重程度。还仔细分析了引发和加重瘙痒症状的所有因素。作者评估了瘙痒与身体质量指数（BMI）和疾病严重程度的关系。分析血清白细胞介素17 （IL-17）和IL-31水平与银屑病活动性和严重程度指数、BMI和瘙痒严重程度的关系。材料与方法：研究对象为60例斑块型银屑病患者。通过问卷调查分析瘙痒对患者生活质量的影响及恶化因素。使用两个独立的量表评估瘙痒的严重程度。采用免疫分析法测定30例牛皮癣患者和10例健康对照者血清IL-17和IL-31水平。结果：88.3%的患者有瘙痒症状，压力是加重瘙痒最常见的因素（39.6%）。银屑病患者瘙痒与性别、病程、皮损程度无关。瘙痒的平均强度评估为中度，与BMI水平、IL-17和IL-31无显著相关性。结论：银屑病瘙痒的发病机制尚不完全清楚，有待进一步深入研究。瘙痒可视为牛皮癣的一个特征性特征，除皮肤病变外，还应作为皮肤科治疗的一个目标，以提高患者的生活质量。
Introduction: According to available data, pruritus is a common symptom of psoriasis, however its characteristics and pathogenesis are not clearly understood.Aim: The main aim of this study was to assess itching sensation among patients suffering from psoriasis, including its incidence and severity. All factors triggering and worsening pruritic symptoms were also carefully analyzed. The authors assessed the relationship of itch with body mass index (BMI) and severity of disease. Moreover, serum levels of interleukin 17 (IL-17) and IL-31 were analyzed in relation to Psoriasis Activity and Severity Index, BMI and severity of pruritus.Material and methods: The study group consisted of 60 patients with plaque-type psoriasis. Analysis of impact of pruritus on the quality of life and worsening factors was based on the questionnaire. The severity of pruritus was assessed with the use of two independent scales. Serum IL-17 and IL-31 levels were measured in 30 patients suffering from psoriasis and in 10 healthy controls using immunoassay tests.Results: 88.3% of analyzed patients complained of itch and the most common factor which exacerbated pruritus was stress (39.6%). Pruritus in psoriasis was independent of gender, illness duration and extent of skin lesions. The average intensity of pruritus was assessed as moderate and did not correlate significantly with BMI level, IL-17 and IL-31.Conclusions: Since the pathogenesis of pruritus in psoriasis is not fully understood, further investigation in this area needs to be conducted. Pruritus may be considered as a characteristic feature of psoriasis and, besides the skin lesions, should be a target in dermatological treatment to improve patient's quality of life.