CELIAC-DISEASE, ENAMEL DEFECTS AND HLA TYPING
CELIAC-DISEASE, ENAMEL DEFECTS AND HLA TYPING
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DOI：
10.1111/j.1651-2227.1994.tb13014.x
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发表时间：
1994-12-01
期刊：
影响因子：
3.8
通讯作者：
BONAMICO, M
中科院分区：
文献类型：
--
作者：
MARIANI, P;MAZZILLI, MC;BONAMICO, M
对82例意大利乳糜泻患儿的牙釉质缺陷及其与低钙血症或特定HLA类的关系进行了研究。在23名受试者（第1组）中检测到分界混浊或发育不全，而在其余59名患者（第2组）中发现最小或无牙齿病变;在189名正常对照组中，釉质病变的频率明显低于乳糜泻患者（14.8%对28.0%; p < 0.005）。第1组和第2组之间的诊断年龄和钙浓度无统计学显著差异。回归分析显示，年龄之间的相关性诊断和牙釉质缺损的牙齿数量。在我们的患者中，HLADR 3抗原的存在显著增加了牙齿损伤的风险，而DR 5，7基因型似乎可以防止釉质缺损。Logistic回归分析的变量年龄，血清钙浓度，受影响的牙齿，类型的釉质缺损和DR抗原的数量表明，只有DR抗原区分腹腔疾病患者从那些没有釉质缺损。
The presence of dental enamel defects in coeliac disease and their relation to hypocalcaemia or a particular HLA class in 82 Italian children with coeliac disease was studied. Demarcated opacities or hypoplasia were detected in 23 subjects (group 1) while minimal or no dental lesions were found in the remaining 59 patients (group 2); in 189 normal controls, enamel lesions were significantly less frequent than in patients with coeliac disease (14.8% versus 28.0%; p < 0.005). No statistically significant differences were found for age at diagnosis and calcium concentrations between groups 1 and 2. Regression analysis showed a correlation between age at diagnosis and number of teeth with enamel defects. In our patients, the presence of HLA DR3 antigen significantly increased the risk of dental lesions, while genotype DR5,7 seemed to protect against enamel defects. A logistic regression analysis of the variables age, serum calcium concentrations, number of affected teeth, type of enamel defect and DR antigens showed that only DR antigens discriminated coeliac disease patients with from those without enamel defects.