Good Prognosis for Follicular Lymphoma with Estrogen Receptor α-positive Follicular Dendritic Cells
Good Prognosis for Follicular Lymphoma with Estrogen Receptor α-positive Follicular Dendritic Cells
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雌激素受体 α 阳性滤泡树突状细胞的滤泡性淋巴瘤预后良好
DOI：
10.1002/hon.2730
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发表时间：
2020
影响因子：
3.3
通讯作者：
Yamakawa Mitsunori
中科院分区：
文献类型：
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作者：
Ohe Rintaro;Meng Hong-Xue;Yamada Akane;Aung Naing Ye;Kabasawa Takanobu;Tamura Yuka;Utsunomiya Aya;Tamazawa Nobuyuki;Kawamura Ichiro;Kitaoka Takumi;Suzuki Kazushi;Yanagiya Ryo;Toubai Tomomi;Ishizawa Kenichi;Yamakawa Mitsunori
滤泡性淋巴瘤（FL）具有滤泡性树突状细胞（FDCs）网络。我们先前证实了1 - 2级FL中存在雌激素受体α（ERα）+CD 23 + FDC。FDC作为FL预后因素的意义尚不清楚。本研究旨在比较ERα+ FDCs和ERα+FDCs的FL的临床病理特征，包括预后。本研究应用免疫组化方法检测了70例FL患者ERα表达的临床病理意义。5例FL患者FDCs经免疫组化和原位杂交证实ER αmRNA表达。我们将ERα频繁表达的患者定义为ERα高表达组，ERα不频繁表达的患者定义为ERα低表达组。32例患者被分配到ERα高组（45.7%），38例患者被分配到ERα低组（54.3%）。ERα高表达组的总生存期（OS）和无进展生存期（PFS）均显著优于ERα低表达组（OS，log rank，P= 0.0465; PFS，log rank，P= 0.0336）。此外，ERα在FDCs上的高表达是OS的独立预后因素，（[风险比] HR，0.163;P= .0260）和多变量（HR，0.050;P= .0188）分析和单变量PFS分析ERαmRNA在FL患者肿瘤性卵泡内的CD 21 +FDCs中表达。总之，ERα阳性FDC的肿瘤性滤泡微环境可能影响FL滤泡模式的分级和存在，并改善患者预后。
Follicular lymphoma (FL) has a meshwork of follicular dendritic cells (FDCs). We previously demonstrated the presence of estrogen receptor alpha (ERα)+CD23+FDCs in grades 1‐2 FL. The significance of FDCs as a prognostic factor in FL remains unknown. The current study aimed to compare clinicopathological features, including prognosis, between FL with and without ERα+FDCs. This study evaluated the clinicopathological significance of ERα expression in 70 FL patients by immunostaining. The presence ofERαmRNA on FDCs from 5 FL patients was confirmed by CD21/ERαdouble staining (immunohistochemistry and in situ hybridization). We defined patients with frequent ERα expression as the ERαhighgroup and those with infrequent ERα expression as the ERαlowgroup. Thirty‐two patients were assigned to the ERαhighgroup (45.7%), and 38 patients were assigned to the ERαlowgroup (54.3%). Both overall survival (OS) and progression‐free survival (PFS) were significantly better in the ERαhighgroup than in the ERαlowgroup (OS, log‐rank,P= .0465; PFS, log‐rank,P= .0336). Moreover, high ERα expression on FDCs was an independent prognostic factor for OS in both the univariate ([hazard ratio] HR, 0.163;P= .0260) and multivariate (HR, 0.050;P= .0188) analyses and for PFS in both the univariate (HR, 0.232;P= .0213) and multivariate (HR, 0.084;P= .0243) analyses.ERαmRNA expression was detected in CD21+FDCs within the neoplastic follicles of FL patients. In conclusion, a neoplastic follicular microenvironment with ERα‐positive FDCs might affect the grade and presence of the follicular pattern of FL and improve patient prognosis.