Chemical constituent from the roots ofSolanum melongenaL. and their potential anti-inflammatory activity
Chemical constituent from the roots ofSolanum melongenaL. and their potential anti-inflammatory activity
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DOI：
10.1080/14786419.2020.1815740
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发表时间：
2020-09-02
影响因子：
2.2
通讯作者：
Kuang, Hai-Xue
中科院分区：
文献类型：
--
作者：
Liu, Yan;Yin, Xin;Kuang, Hai-Xue
从茄科植物茄茄Solanum melongenaL.的乙醇提取物中分离得到三个新化合物（1-3），共27个已知数（4-30）。根据1D和2D NMR数据，结合HR-MS和文献中的相对值，确定了分离化合物的化学结构。此外，通过脂多糖（LPS）诱导的RAW 264.7细胞模型体外抑制一氧化氮（NO）的产生来评价分离物的潜在抗炎活性。化合物12和21显示出中等程度的NO生成抑制作用，IC（50）值分别为32.8和20.2 μ M。
Three new compounds (1-3), were isolated from the ethanol extract of the roots ofSolanum melongenaL., together with twenty-seven knowns (4-30). On basis of their 1 D and 2 D NMR data, the chemical structures of islated compounds were elucidated combined with HR-MS and the relative values in literatures. In addition, the isolations were evaluated for the potential anti-inflammatory activity, by virtue of RAW 264.7 cells model induced by lipopolysaccharide (LPS)in vitro inhibitory activities on nitric oxide (NO) production. Compounds12and21showed moderate inhibition of NO production with IC(50)values of 32.8 and 20.2 mu M, respectively.