Mechanism of sodium load-induced hypertension in non-insulin dependent diabetes mellitus model rats: Defective dopaminergic system to inhibit Na-K-ATPase activity in renal epithelial cells
Mechanism of sodium load-induced hypertension in non-insulin dependent diabetes mellitus model rats: Defective dopaminergic system to inhibit Na-K-ATPase activity in renal epithelial cells
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DOI：
10.1291/hypres.24.127
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发表时间：
2001-03-01
影响因子：
5.4
通讯作者：
Owada, S
中科院分区：
文献类型：
--
作者：
Tsuchida, H;Imai, G;Owada, S
肥胖相关的非胰岛素依赖型糖尿病（NIDDM）经常伴有高血压。本研究旨在阐明这一机制。本研究首先测定了NIDDM模型大鼠之一的Wistar肥胖大鼠（WFR）和对照组Wistar瘦大鼠（WLR）的血压，并分别给予正常（0.7%NaCl）和高盐（7%NaCl）饮食。我们观察到WFR和WLR之间的收缩压和平均血压无差异，但由于摄入高盐饮食，WFR变得非常高血压。我们接下来研究了WFR中钠敏感性的机制，尽管在WFR中保留了多巴胺（DA）的尿排泄，这是一种有效的利钠因子，反映了肾脏DA产生的能力，但高盐饮食的钠平衡是积极的。此外，正常盐饮食的WFR离体近曲小管（PCT）的Na-K-ATP酶活性显著（p
Obesity-related non-insulin dependent diabetes mellitus (NIDDM) is frequently accompanied by hypertension. The present study was designed to clarify this mechanism. We first determined the blood pressure in male Wistar fatty rats (WFR), one of the NIDDM model rats, and in Wistar lean rats (WLR) as the control, with a normal(0.7% NaCl) or high (7% NaCl) salt diet. We observed no difference in systolic and mean blood pressures between WFR and WLR, WFR, however, became extremely hypertensive as a result of ingesting the high salt diet. We next investigated the mechanism for sodium sensitivity in WFR, Although the urinary excretion of dopamine (DA), a potent natriuretic factor, which reflects the ability for renal DA production, was preserved in WFR, the sodium balance with the high salt diet was positive. Moreover, Na-K-ATPase activity in isolated proximal convoluted tubules (PCT) from WFR with a normal salt diet was significantly (p