Skin Regeneration for Giant Pigmented Nevus Using Autologous Cultured Dermal Substitutes and Epidermis Separated From Nevus Skin
Skin Regeneration for Giant Pigmented Nevus Using Autologous Cultured Dermal Substitutes and Epidermis Separated From Nevus Skin
复制标题
使用自体培养真皮替代品和从痣皮肤分离的表皮进行巨大色素痣的皮肤再生
DOI：
10.1097/01.sap.0000197199.40281.76
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发表时间：
2006
影响因子：
1.5
通讯作者：
Y. Kuroyanagi
中科院分区：
文献类型：
--
作者：
Shinji Kobayashi;K. Kubo;Hiromichi Matsui;K. Torikai;Y. Kuroyanagi
我们开发了一种治疗皮内型巨大色素痣的方法。该方法涉及应用自体培养真皮替代物（CDS），然后移植从患者痣皮肤分离的表皮。为了准备伤口床，在痣完全切除后，将自体 CDS 应用于全层皮肤缺损。将切除的痣皮肤保存1周，然后通过分散酶的酶处理将表皮与痣皮肤分离。将由此获得的表皮移植到所得创面床上。该手术用于治疗一名 7 岁患者的巨大色素痣。表皮移植一年后，移植区域柔软，色调良好。这些结果表明，本方法可以实现巨痣的完全切除，并且具有美学上可接受的结果，尽管需要长时间的仔细监测。
We have developed a modality of treatment of giant pigmented nevus of intradermal type. This method involves application of autologous cultured dermal substitute (CDS), followed by grafting of epidermis separated from the patient's nevus skin. To prepare the wound bed, autologous CDS was applied onto a full-thickness skin defect after complete excision of the nevus. The excised nevus skin was preserved for 1 week, after which the epidermis was separated from the nevus skin by enzymatic treatment with dispase. The epidermis thus obtained was grafted onto the resulting wound bed. This procedure was used to treat a giant pigmented nevus on a 7-year-old patient. The grafted region was soft with good tone 1 year after epidermis grafting. These results indicate that the present method can achieve complete excision of giant nevus, with esthetically acceptable results, although it requires careful monitoring for a long time.
同种异体培养真皮替代物治疗三例隐性营养不良性大疱性表皮松解症患者顽固性皮肤溃疡的临床试验
DOI：
--
发表时间：
2004
期刊：
J Am Acad Dermatol 50
影响因子：
--
作者：
Hasegawa T;Suga Y;Ikeda S;et al.
通讯作者：
et al.
与特发性嗜酸性粒细胞增多相关的指坏疽：用同种异体培养真皮替代物（CDS）治疗
DOI：
--
发表时间：
2004
期刊：
Eur J Dermatol 14
影响因子：
--
作者：
Ohtani T;Okamoto K;Kaminaka C;Kishi T;Sakurane M;Yamamoto Y;Uede K;Kubo K;Kuroyanagi Y;Furukawa F
通讯作者：
Furukawa F