Type 2 diabetes mellitus and the risk of open-angle glaucoma - The Los Angeles Latino Eye Study
Type 2 diabetes mellitus and the risk of open-angle glaucoma - The Los Angeles Latino Eye Study
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DOI：
10.1016/j.ophtha.2007.04.049
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发表时间：
2008-02-01
期刊：
影响因子：
13.7
通讯作者：
Azen, Stanley P.
中科院分区：
文献类型：
--
作者：
Chopra, Vikas;Varma, Rohit;Azen, Stanley P.
目的：研究拉丁裔成年人2型糖尿病（T2DM）与开角型青光眼（OAG）风险之间的关系。设计：基于人群的横断面研究。参与者：来自加州洛杉矶6个人口普查区40岁及以上的拉丁裔（n = 5894）。方法：来自洛杉矶拉丁美洲人眼研究（LALES）的参与者回答了一份由访谈者管理的问卷，并接受了临床和完整的眼部检查，包括视野（VF）测试和立体眼底摄影。如果参与者有糖尿病治疗史，糖化血红蛋白测量值为7.0%或更高，或者随机血糖为200mg %或更高，则参与者被定义为糖尿病（DM）。2型糖尿病定义为参与者在确诊为糖尿病时年龄为30岁或以上。开角型青光眼定义为至少一只眼睛存在开角和青光眼VF异常和/或青光眼视盘损伤的证据。采用Logistic回归分析确定T2DM患者发生OAG的风险。主要结局指标：OAG的患病率。结果：在5894名数据完整的参与者中，1157名（19.6%）患有T2DM， 288名（4.9%）患有OAG。T2DM患者的OAG患病率比非T2DM患者高40%（年龄/性别/眼压校正比值比为1.4；95%可信区间为1.03-1.8;P = 0.03）。趋势分析显示，T2DM病程越长（以5年为单位分层），OAG患病率越高(P
Purpose: To examine the relationship between type 2 diabetes mellitus (T2DM) and the risk of having open-angle glaucoma (OAG) in an adult Latino population.Design: Population-based cross-sectional study.Participants: Latinos 40 years and older (n = 5894) from 6 census tracts in Los Angeles, California.Methods: Participants from the Los Angeles Latino Eye Study (LALES), a large population-based study of self-identified adult Latinos, answered an interviewer-administered questionnaire and underwent a clinical and complete ocular examination, including visual field (VF) testing and stereo fundus photography. A participant was defined as having diabetes mellitus (DM) if she or he had a history of being treated for DM, the participant's glycosylated hemoglobin was measured at 7.0% or higher, or the participant had random blood glucose of 200 mg% or higher. Type 2 DM was defined if the participant was 30 years or older when diagnosed with DM. Open-angle glaucoma was defined as the presence of an open angle and a glaucomatous VF abnormality and/or evidence of glaucomatous optic disc damage in at least one eye. Logistic regression analysis was used to identify the risk of having OAG in persons with T2DM.Main Outcome Measure: Prevalence of OAG.Results: Of the 5894 participants with complete data, 1157 (19.6%) had T2DM and 288 (4.9%) had OAG. The prevalence of OAG was 40% higher in participants with T2DM than in those without T2DM (age/gender/ intraocular pressure-adjusted odds ratio, 1.4; 95% confidence interval, 1.03-1.8; P = 0.03). Trend analysis revealed that a longer duration of T2DM (stratified into 5-year increments) was associated with a higher prevalence of OAG (P