C. elegans episodic swimming is driven by multifractal kinetics
C. elegans episodic swimming is driven by multifractal kinetics
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DOI：
10.1038/s41598-020-70319-0
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发表时间：
2020-09-08
影响因子：
4.6
通讯作者：
Sako，Yasushi
中科院分区：
文献类型：
--
作者：
Ikeda，Yusaku;Jurica，Peter;Sako，Yasushi
分形尺度是动物行为的各种模式中时间变化的共同属性。动物行为中分形标度的分子机制在很大程度上尚未探索。线虫C. elegans在液体溶液中在游泳和静止状态之间交替。在这里，我们报告说，C。elegansepisodic游泳的特点是无标度动力学与长期的时间相关性和局部时间集群，即符合多重分形动力学。在主动移动和非主动状态的停留时间分布在幂律为基础的无标度的方式。多重分形分析表明，活动状态和非活动状态的时间相关性和时间聚类性明显不同。这些结果表明C.优雅游泳是由两种行为状态之间的转换驱动的，其中两种转换动力学中的每一种都遵循不同的多重分形动力学。我们发现，一个保守的行为调节剂，环GMP依赖性激酶（PKG）可以调节动物行为的多重分形动力学。我们的组合分析方法，涉及分子遗传学和动力学提供了一个平台的分子解剖的分形性质的生理和行为现象。
Fractal scaling is a common property of temporal change in various modes of animal behavior. The molecular mechanisms of fractal scaling in animal behaviors remain largely unexplored. The nematodeC. elegansalternates between swimming and resting states in a liquid solution. Here, we report thatC. elegansepisodic swimming is characterized by scale-free kinetics with long-range temporal correlation and local temporal clusterization, namely consistent with multifractal kinetics. Residence times in actively-moving and inactive states were distributed in a power law-based scale-free manner. Multifractal analysis showed that temporal correlation and temporal clusterization were distinct between the actively-moving state and the inactive state. These results indicate thatC. elegansepisodic swimming is driven by transition between two behavioral states, in which each of two transition kinetics follows distinct multifractal kinetics. We found that a conserved behavioral modulator, cyclic GMP dependent kinase (PKG) may regulate the multifractal kinetics underlying an animal behavior. Our combinatorial analysis approach involving molecular genetics and kinetics provides a platform for the molecular dissection of the fractal nature of physiological and behavioral phenomena.