The significance of Survivin and Nectin-4 expression in the prognosis of breast carcinoma
The significance of Survivin and Nectin-4 expression in the prognosis of breast carcinoma
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DOI：
10.5603/fhc.2011.0005
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发表时间：
2011-01-01
影响因子：
1.5
通讯作者：
Athanassiadou, Pauline
中科院分区：
文献类型：
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作者：
Athanassiadou, Anna Maria;Patsouris, Efstratios;Athanassiadou, Pauline
探讨乳腺癌中Survivin和Nectin-4表达的预后意义。从 140 个乳腺癌标本中获取印迹涂片，并通过免疫细胞化学研究 Survivin 和 Nectin-4 的表达。结果与一些临床病理学参数相关，包括五年生存率。 Survivin 染色模式的增加与分级增加 (p < 0.0001)、淋巴结侵袭增加 (p < 0.0001)、肿瘤大小增加和生存率降低 (p < 0.0001) 相关。 Nectin-4 表达升高还与肿瘤分级增加 (p < 0.0001)、肿瘤大小增加 (p < 0.0001) 和生存率降低 (p < 0.0001) 显着相关。此外，Survivin 和 Nectin-4 染色模式彼此密切相关 (p < 0.0001)。然而，根据多变量分析，在我们的研究病例中，Survivin 和 Nectin-4 表达似乎都对生存没有独立影响。我们的研究结果表明，Survivin 和 Nectin-4 表达增加可能表明乳腺癌患者的预后较差。这些标志物的表达对乳腺癌预后和治疗的确切影响仍有待阐明。 （Folia Histochemica et Cytobiologica 2011；第 49 卷，第 1 期，第 26-33 页）
To investigate the prognostic significance of Survivin and Nectin-4 expression in breast carcinomas. Imprint smears were obtained from 140 breast carcinoma specimens and studied immunocytochemically for the expression of Survivin and Nectin-4. The results were correlated with several clinicopathological parameters, including five-year survival. Increased Survivin staining pattern correlated with increased grade (p < 0.0001), increased lymph node invasion (p < 0.0001), increased tumor size and reduced survival (p < 0.0001). Elevated Nectin-4 expression also correlated significantly with increased grade (p < 0.0001), increased tumor size (p < 0.0001) and reduced survival (p < 0.0001). In addition, Survivin and Nectin-4 staining patterns correlated strongly with one another (p < 0.0001). However, on multivariate analysis, neither Survivin nor Nectin-4 expression seemed to have an independent impact on survival in our study cases. The findings of our study suggest that increased expression of Survivin and Nectin-4 may indicate a worse prognosis in breast cancer patients. The exact implications of the expression of these markers in breast cancer prognosis and treatment remain to be clarified. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 1, pp. 26-33)