Adenosquamous differentiation in mammary carcinoma: an ultrastructural and steroid receptor study.
Adenosquamous differentiation in mammary carcinoma: an ultrastructural and steroid receptor study.
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乳腺癌的腺鳞分化：超微结构和类固醇受体研究。
DOI：
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发表时间：
1980
影响因子：
4.6
通讯作者：
K. Mccarty
中科院分区：
文献类型：
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作者：
B. Woodard;A. Brinkhous;K. Mccarty;K. Mccarty
光镜下5例仅为鳞状细胞的乳腺癌表现出相同单个细胞内鳞状细胞和腺瘤分化的超微结构特征。五例中有两例表现出定量低水平的饱和雌激素和/或孕酮结合蛋白。在任何情况下，都没有指示临床激素反应潜力的受体的定量或定性模式。建议对乳腺原发性鳞状细胞癌进行超微结构检查，以确定腺鳞状分化，因为在1，760例（0.3%）乳腺癌的前瞻性研究中观察到的5种明显鳞状细胞癌中的每一种都在超微结构上表现出腺鳞状分化。
Five breast carcinomas with only squamous morphology by light microscopy demonstrated ultrastructural features of both squamous and adenomatous differentiation within the same individual cells. Two of the five cases demonstrated quantitatively low levels of saturable estrogen- and/or progesterone-binding proteins. In no case were there quantitative or qualitative patterns of receptors indicative of clinical hormonal response potential. It is suggested that primary squamous cell carcinomas of the breast should be examined ultrastructurally for adenosquamous differentiation as each of the five apparent squamous carcinomas observed in a prospective study of 1,760 (0.3%) cases of breast cancer demonstrated adenosquamous differentiation ultrastructurally.