Associations between body composition and gait-speed decline: results from the Health, Aging, and Body Composition study
Associations between body composition and gait-speed decline: results from the Health, Aging, and Body Composition study
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DOI：
10.3945/ajcn.112.047860
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发表时间：
2013-03-01
影响因子：
7.1
通讯作者：
Kritchevsky, Stephen B.
中科院分区：
文献类型：
--
作者：
Beavers, Kristen M.;Beavers, Daniel P.;Kritchevsky, Stephen B.
背景：在老年人中，步态速度每减慢0.1 m/s，死亡率就增加12%。然而，很少有研究已经确定了危险因素的步态速度decline.Objective：我们评估了几个措施的身体成分和年龄相关的下降之间的关联在步态speeds.Design：数据来自2306老年人谁参加了健康，老龄化和身体成分队列，并随后为4年（50%的妇女，38%的黑人）。步行速度（m/s）超过20米，在第2年至第6年进行了测量，并在几个措施的身体组成的基线和变化包括在mixed-effects models.Results：步态速度下降了0.06 +/- 0.00米/秒的4年期间。基线大腿肌间脂肪预测男性和女性的年步态速度下降（+/-SE）（分别为-0.01 +/- 0.00和-0.02 +/- 0.00 m/s/0.57 cm 2; P < 0.01）。在男性中，而不是在女性中，这种关系是独立的全身肥胖。在纵向分析中，大腿肌间脂肪和大腿总肌肉的变化是唯一预测男女步态速度下降的身体成分指标。当一起建模时，大腿肌间脂肪每增加5.75-cm（2）与步态速度降低0.01 +/- 0.00-m/s相关，而大腿肌肉每减少16.92-cm（2）与步态速度降低0.01 +/- 0.00-m/s相关。大腿肌间脂肪的增加是步态速度下降的重要预测因素，这意味着脂肪浸润到肌肉中有助于随着年龄的增长而丧失流动性。相反，大腿肌肉面积的减少也预示着步态速度的下降。美国临床营养杂志2013;97：552-60。
Background: In older adults, every 0.1-m/s slower gait speed is associated with a 12% higher mortality. However, little research has identified risk factors for gait-speed decline.Objective: We assessed the association between several measures of body composition and age-related decline in gait speed.Design: Data were from 2306 older adults who were participating in the Health, Aging, and Body Composition cohort and were followed for 4 y (50% women; 38% black). Usual walking speed (m/s) over 20 m was measured in years 2 through 6, and the baseline and changes in several measures of body composition were included in mixed-effects models.Results: Gait speed declined by 0.06 +/- 0.00 m/s over the 4-y period. Baseline thigh intermuscular fat predicted the annual gait-speed decline (+/-SE) in both men and women (-0.01 +/- 0.00 and -0.02 +/- 0.00 m/s per 0.57 cm(2), respectively; P < 0.01). In men, but not in women, this relation was independent of total body adiposity. In longitudinal analyses, changes in thigh intermuscular fat and total thigh muscle were the only body-composition measures that predicted gait-speed decline in men and women combined. When modeled together, every 5.75-cm(2) increase in thigh intermuscular fat was associated with a 0.01 +/- 0.00-m/s decrease in gait speed, whereas every 16.92-cm(2) decrease in thigh muscle was associated with a 0.01 +/- 0.00-m/s decrease in gait speed.Conclusions: High and increasing thigh intermuscular fat are important predictors of gait-speed decline, implying that fat infiltration into muscle contributes to a loss of mobility with age. Conversely, a decreasing thigh muscle area is also predictive of a decline in gait speed. Am J Clin Nutr 2013;97:552-60.