CD22 regulates time course of both B cell division and antibody response
CD22 regulates time course of both B cell division and antibody response
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DOI：
10.4049/jimmunol.180.2.907
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发表时间：
2008-01-15
影响因子：
4.4
通讯作者：
Tsubata, Takeshi
中科院分区：
文献类型：
--
作者：
Onodera, Taishi;Poe, Jonathan C.;Tsubata, Takeshi
由于病原体以时间依赖的方式诱发感染症状，快速的免疫反应有利于防御病原体，特别是那些引起急性传染病的宿主。然而，免疫反应的时间进程是如何调节的在很大程度上是未知的。在这项研究中，我们证明了缺乏抑制性辅助受体CD22的B细胞在Ag刺激后会加速细胞分裂，导致浆细胞的快速产生和抗体的产生。这一发现表明，CD22调节B细胞反应的时间进程，并提示CD22是一个很好的靶点，可以缩短抗体产生所需的时间，从而增强宿主对急性传染病的抵抗力，即“普遍接种”。
Because pathogens induce infectious symptoms in a time-dependent manner, a rapid immune response is beneficial for defending hosts from pathogens, especially those inducing acute infectious diseases. However, it is largely unknown how the time course of immune responses is regulated. In this study, we demonstrate that B cells deficient in the inhibitory coreceptor CD22 undergo accelerated cell division after Ag stimulation, resulting in rapid generation of plasma cells and Ab production. This finding indicates that CD22 regulates the time course of B cell responses and suggests that CD22 is a good target to shorten the time required for Ab production, thereby augmenting host defense against acute infectious diseases as "universal vaccination".