Daytime colour preference in Drosophila depends on the circadian clock and TRP channels
Daytime colour preference in Drosophila depends on the circadian clock and TRP channels
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DOI：
10.1038/s41586-019-1571-y
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发表时间：
2019-10-03
期刊：
影响因子：
64.8
通讯作者：
Syed, Sheyum
中科院分区：
文献类型：
--
作者：
Lazopulo, Stanislav;Lazopulo, Andrey;Syed, Sheyum
根据颜色的光辨别可以通过引导动物走向食物和住所以及远离潜在的有害环境来赋予生存优势（1，2）。这种依赖颜色的行为可能是后天习得的，也可能是天生的。关于哺乳动物先天颜色偏好的数据仍然存在争议（3），对于简单生物的数据有限（4-7）。在这里，我们表明，当在蓝色，绿色和昏暗的光线中进行选择时，果蝇表现出一种出乎意料的复杂的颜色偏好模式，该模式根据一天中的时间而变化。苍蝇在清晨和下午晚些时候对绿色表现出强烈的偏好，中午对绿色的偏好降低，全天对蓝色表现出强烈的回避。遗传操作揭示了绿色偏好的峰值需要基于视紫红质的视觉光感受器，并且由生物钟控制。中午减少绿色偏好有利于昏暗的光取决于瞬时受体电位（TRP）通道dTRPA 1和发热，也是由时钟计时。相比之下，对蓝光的回避主要由多树突神经元介导，需要视紫红质7和TRP通道Painless，并且不依赖于时钟。我们的研究结果表明，几个TRP通道参与了果蝇的颜色驱动行为，并揭示了先天颜色偏好的不同途径，协调苍蝇在环境光下的行为动力学。
Light discrimination according to colour can confer survival advantages by guiding animals towards food and shelter and away from potentially harmful situations(1,2). Such colour-dependent behaviour can be learned or innate. Data on innate colour preference in mammals remain controversial(3) and there are limited data for simpler organisms(4-7). Here we show that, when given a choice among blue, green and dim light, fruit flies exhibit an unexpectedly complex pattern of colour preference that changes according to the time of day. Flies show a strong preference for green in the early morning and late afternoon, a reduced green preference at midday and a robust avoidance of blue throughout the day. Genetic manipulations reveal that the peaks in green preference require rhodopsin-based visual photoreceptors and are controlled by the circadian clock. The midday reduction in green preference in favour of dim light depends on the transient receptor potential (TRP) channels dTRPA1 and Pyrexia, and is also timed by the clock. By contrast, avoidance of blue light is primarily mediated by multidendritic neurons, requires rhodopsin 7 and the TRP channel Painless, and is independent of the clock. Our findings show that several TRP channels are involved in colour-driven behaviour in Drosophila, and reveal distinct pathways of innate colour preference that coordinate the behavioural dynamics of flies in ambient light.