Cytostatic factor: an activity that puts the cell cycle on hold
Cytostatic factor: an activity that puts the cell cycle on hold
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DOI：
10.1242/jcs.02919
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发表时间：
2006-04-01
影响因子：
4
通讯作者：
Mayer, TU
中科院分区：
文献类型：
--
作者：
Schmidt, A;Rauh, NR;Mayer, TU
Fertilization is the fundamental process in which two gametes-sperm and oocyte-fuse to generate a zygote that will form a new multicellular organism. In most vertebrates, oocytes await fertilization while arrested at metaphase of meiosis II. This resting state can be stable for many hours and depends on a cytoplasmic activity termed cytostatic factor (CSF). Recently, members of the novel Emi/Erp family of proteins have been put forward as important components of CSF. These proteins inhibit the anaphase-promoting complex/cyclosome (APC/C), which acts at the very core of the cell cycle regulatory machinery. Initially, Xenopus early mitotic inhibitor 1 (Emi1) was proposed to be a component of CSF, but newer work suggests that a structural relative, Emi-related protein 1 (Erp1/Emi2), is essential for maintenance of CSF arrest in Xenopus. Most importantly, studies on Erp1/Emi2 regulation have led to a detailed molecular understanding of the Ca2+-mediated release from CSF arrest that occurs upon fertilization.
