Clinical manifestations of arrhythmogenic right ventricular cardiomyopathy in Korean patients
Clinical manifestations of arrhythmogenic right ventricular cardiomyopathy in Korean patients
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DOI：
10.1016/j.ijcard.2006.11.070
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发表时间：
2007-11-01
影响因子：
3.5
通讯作者：
Park, Wee-Hyun
中科院分区：
文献类型：
--
作者：
Cho, Yongkeun;Park, Taein;Park, Wee-Hyun
背景资料：结果：37例ARVC患者（41.2 ± 14.8岁，男性19例）被诊断为ARVC。最常见的临床症状为心悸（30%）、晕厥/晕厥前期（30%）和无症状（30%）。4例患者有过早猝死或ARVC家族史。由于ECG异常或无症状性室性心律失常，对大多数无症状患者进行了评价。室性心动过速、室颤和频繁的室性期前收缩分别为35%、5%和24%。左、右室壁运动异常检出率分别为92%和41%。在32例接受肌内膜活检的患者中，26例（81%）观察到脂肪或纤维脂肪浸润。两名患者有心力衰竭的迹象。2例晕厥/晕厥前期患者被诊断为血管迷走神经性晕厥，另1例是由于药物副作用。大多数室性心律失常患者接受β受体阻滞剂和/或胺碘酮治疗。3例患者植入了植入式心脏复律器（ICD）。在平均随访27.4+/-26.5个月，没有晕厥或猝死的发展，除了在一个ICD谁遭受反复休克，由于ventricular fibrillation.Conclusions：ARVC可能是一个重要的原因晕厥，室性心律失常，心电图和室壁运动异常的心室在韩国。韩国ARVC患者表现出各种临床表现。(C)2006爱思唯尔爱尔兰有限公司保留所有权利。
Background: The clinical manifestations of the Korean patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) are not well known.Methods: The clinical data of Korean patients who met the Task Force Criteria for ARVC were analyzed.Results: Thirty-seven patients (41.2+/-14.8 years old, 19 males) were diagnosed with ARVC. The commonest presenting symptoms were palpitations (30%), syncope/presyncope ( 30%) and no symptoms ( 30%). Four patients had a family history of premature sudden death or ARVC. Most patients with no symptoms were evaluated due to ECG abnormalities or asymptomatic ventricular arrhythmias. Ventricular tachycardia, ventricular fibrillation and frequent premature ventricular contractions only were observed in 35%, 5% and 24%, respectively. Wall motion abnormalities of the right and left ventricles were detected in 92% and 41%, respectively. Fatty or fibrofatty infiltration was observed in 26 of the 32 (81%) patients who underwent an endomyocardial biopsy. Two patients had signs of heart failure. Two patients with syncope/presyncope were diagnosed with vasovagal syncope and another was due to side effects from a medication. Most of the patients with ventricular arrhythmias were treated with beta-blockers and/or amiodarone. Implantable cardioverter-defibrillators (ICDs) were implanted in 3 patients. During a mean follow-up of 27.4+/-26.5 months no syncope or sudden death developed except for in one patient with an ICD who suffered from recurrent shocks due to ventricular fibrillation.Conclusions: ARVC may be an important cause of syncope, ventricular arrhythmias, and ECG and wall motion abnormalities of the ventricles in Koreans. The Korean patients with ARVC exhibited various clinical manifestations. (C) 2006 Elsevier Ireland Ltd. All rights reserved.