Myofibroblast:: A prognostic marker and target cell in progressive renal disease
Myofibroblast:: A prognostic marker and target cell in progressive renal disease
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DOI：
10.1081/jdi-100104736
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发表时间：
2001-01-01
期刊：
影响因子：
3
通讯作者：
Desmoulière, A
中科院分区：
文献类型：
--
作者：
Badid, C;Vincent, M;Desmoulière, A
肌成纤维细胞在许多组织损伤中起重要作用，特别是在肾脏疾病中。肌成纤维细胞分化是纤维化发展的早期事件。肌成纤维细胞样细胞表达平滑肌（SM）细胞骨架标志物（特别是α-SM肌动蛋白）并积极参与细胞外基质的产生。早期危险因素的识别，特别是组织学标准，可能有助于识别有进展性肾衰竭风险和需要治疗的患者。评价肾组织中肌成纤维细胞的分化程度可以反映组织损伤的强度，预测慢性肾脏病的长期预后，并帮助医生选择治疗方案。肌成纤维细胞不仅是疾病活动性指标，而且似乎是进展性肾病未来治疗的关键靶点。
Myofibroblasts play an important role in many tissue injuries, and particularly in renal disease. The myofibroblast differentiation is an early event in the development of fibrosis. Myofibroblast-like cells express smooth muscle (SM} cytoskeletal markers (a-SM actin in particular) and participate actively in the production of extracellular matrix. Identification of early risk factors, particularly histological criteria, could be useful to identify patients at risk of progressive renal failure and needing a treatment. The evaluation of myofibroblast differentiation in renal tissue may reflect the intensity of tissue injury, predict long term outcome of chronic renal disease and help physicians to select therapeutic choices. More than a disease activity indicator, myofibroblasts appear to be a pivotal target for future therapies in progressive renal disease.