Programmable bio-ionic liquid functionalized hydrogels for in situ 3D bioprinting of electronics at the tissue interface
Programmable bio-ionic liquid functionalized hydrogels for in situ 3D bioprinting of electronics at the tissue interface
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DOI：
10.1016/j.mtadv.2023.100352
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发表时间：
2023-03
影响因子：
10
通讯作者：
Vaishali Krishnadoss;Baishali Kanjilal;A. Masoumi;A. Banerjee;Iman Dehzangi;A. Pezhouman;R. Ardehali-R.-Ardeh
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文献类型：
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作者：
Vaishali Krishnadoss;Baishali Kanjilal;A. Masoumi;A. Banerjee;Iman Dehzangi;A. Pezhouman;R. Ardehali-R.-Ardeh
对个性化可穿戴和植入式医疗设备的需求不断增长，催生了对与生命系统连接的电子产品的需求。当前的生物电子学尚未完全解决生物系统和工程电路之间的不匹配问题，从而导致组织损伤和疼痛。因此，开发用于制造在组织界面具有生物相容性的可穿戴电子产品的材料的需求尚未得到满足。在这里，我们开发了一种可定制的明胶基生物墨水，用胆碱生物离子液体 (BIL) 进行功能化，用于组织界面生物电子学的原位 3D 生物打印。所得光交联聚合物是可编程的、透明的、离子传导性的和柔性的。 BIL 通过光交联与明胶甲基丙烯酰 (GelMA) 水凝胶稳定结合，形成 BioGel，它以高分辨率引导离子电流并实现局部电刺激传递。通过改变反应物成分实现可控交联，使 BioGel 生物墨水平台能够直接在皮肤组织上轻松快速地对复杂设计进行原位 3D 生物打印。因此，生物离子改性聚合物代表了一种多功能且广泛适用的生物墨水解决方案，可用于个性化生物电子制造，最大限度地减少组织损伤。
The increased demand for personalized wearable and implantable medical devices has created the need for the generation of electronics that interface with living systems. Current bioelectronics has not fully resolved mismatches between biological systems and engineered circuits, resulting in tissue injury and pain. Thus, there is an unmet need to develop materials for the fabrication of wearable electronics that are biocompatible at the tissue interface. Here, we developed a tailorable gelatin-based bio-ink functionalized with a choline bio-ionic liquid (BIL) for in situ 3D bioprinting of bioelectronics at the tissue interface. The resultant photocrosslinked polymer is programmable, transparent, ion conductive, and flexible. BILs are stably conjugated with a gelatin methacryloyl (GelMA) hydrogel using photocrosslinking to make BioGel, which routes ionic current with high resolution and enables localized electrical stimulation delivery. Controllable crosslinking, achieved by varying reactants composition, allows the BioGel bio-ink platform for easy and rapid in-situ 3D bioprinting of complex designs directly on skin tissue. Bio-ionic modified polymers thus represent a versatile and wide-applicable bio-ink solution for personalized bioelectronics fabrication that minimizes tissue damage.