Effects of non-uniform static magnetic fields on the rate of myosin phosphorylation
Effects of non-uniform static magnetic fields on the rate of myosin phosphorylation
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DOI：
10.1002/bem.10035
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发表时间：
2002-09-01
影响因子：
1.9
通讯作者：
Markov, JM
中科院分区：
文献类型：
--
作者：
Engström, S;Markov, MS;Markov, JM
研究了暴露在由四个永磁体阵列产生的磁场中对肌球蛋白磷酸化的影响。在阵列上的非均匀场的两个横向位置进行了探索，每个位置在设备表面的四个垂直距离上。发现肌球蛋白磷酸化的速率取决于阵列上的横向位置以及与装置表面的距离。方形磁体阵列由轴向磁化的圆柱形钕铁硼永磁体组成，磁极在平面上交替排列（MagnaBloc（TM）治疗仪）。编制了详细的磁阵剂量测定：8个不同暴露位置的平均磁通密度在0.7-86 mT之间。对应的绝对场梯度范围为0.4 ~ 20 T/m。将剂量学结果与实验结果进行比较，我们的结果表明，仅磁场振幅不足以描述该制备过程中磁场的影响。
The effect on myosin phosphorylation from exposure to a magnetic field generated by an array of four permanent magnets was investigated. Two lateral positions in the non-uniform field over the array were explored, each at four vertical distances over the surface of the device. The rate of myosin phosphorylation was found to depend on the position laterally over the array as well as the distance from the device surface. The square magnet array was comprised of axially magnetized, cylindrical NdFeB permanent magnets arranged with poles of alternating polarity in a plane (MagnaBloc(TM) therapeutic device). Detailed dosimetry of the magnet array was compiled: the magnetic flux density averaged over the exposure volume spanned the range 0.7-86 mT for the eight different exposure positions. The corresponding range for the absolute field gradient was 0.4-20 T/m. Comparing the dosimetry to the experimental outcome, our results imply that magnetic field amplitude alone is not sufficient to describe the influence of the field in this preparation.