Early exposure to methylphenidate increases fear responses in an aversive context in adult rats
Early exposure to methylphenidate increases fear responses in an aversive context in adult rats
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DOI：
10.1002/dev.20213
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发表时间：
2007-04-01
影响因子：
2.2
通讯作者：
Mancebo, Silvia E.
中科院分区：
文献类型：
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作者：
Britton, Gabrielle B.;Segan, Andrew T.;Mancebo, Silvia E.
本研究采用经典恐惧条件反射的方法，考察了发育时期给予盐酸哌甲酯对成年期恐惧习得和保留的影响。雄性Sprague-Dawley大鼠从出生后第25天至第39天每天2次给予MPH （2 mg/kg）或生理盐水，并进行PD 81和PD 82的训练和测试。在训练过程中，电击非条件刺激（US）的呈现与听觉条件刺激（CS）明确配对，或者在训练环境中无信号地发生。在训练过程中，无论电击是发出信号还是不发出信号，都没有发现MPH治疗对恐惧获得的影响，但在训练背景下的24项It保留测试显示，在MPH治疗的动物中，接受无信号训练的动物的恐惧反应增强。这些结果支持了最近关于早期发育性MPH治疗导致成年大鼠焦虑样行为增强的报道，并强调了进一步研究针对儿科人群的发育性暴露于兴奋剂的长期影响的必要性。(c) 2007 Wiley期刊公司
The effects of methylphenidate hydrochloride (MPH) administration during development on fear acquisition and retention in adulthood were examined using classical fear conditioning. Male Sprague-Dawley rats were administered MPH (2 mg/kg) or saline twice daily from postnatal day (PD) 25 to 39, and were trained and tested on PD 81 and 82. During training, shock unconditioned stimulus (US) presentations were explicitly paired with an auditory conditioned stimulus (CS) or occurred unsignaled in the training context. No effect of MPH treatment was found during fear acquisition when shock was signaled or unsignaled during training, but 24 It retention tests in the training context revealed enhanced fear responses in MPH-treated animals that received unsignaled training. These results support recent reports of enhanced anxiety-like behaviors in adult rats caused by early developmental MPH treatment and highlight the need,for further research into the long-term effects of developmental exposure to stimulants aimed at pediatric populations. (c) 2007 Wiley Periodicals, Inc.