Fasting Time and Lipid Levels in a Community-Based Population A Cross-sectional Study
Fasting Time and Lipid Levels in a Community-Based Population A Cross-sectional Study
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DOI：
10.1001/archinternmed.2012.3708
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发表时间：
2012-12-10
影响因子：
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通讯作者：
Naugler, Christopher
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文献类型：
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作者：
Sidhu, Davinder;Naugler, Christopher
背景资料：尽管目前的指南建议在空腹状态下测量血脂水平，但最近的研究表明，非空腹血脂谱对食物摄入的反应最小，在预测不良心血管结局方面可能上级空腹水平。本研究的目的是调查禁食时间和血脂levels.Methods之间的关联：横断面检查的实验室数据，包括禁食时间（小时）和血脂结果，在2011年6个月期间在一个大型的社区为基础的队列。数据来自加拿大阿尔伯塔卡尔加里的卡尔加里实验室服务公司，该公司是卡尔加里及周边地区实验室服务的唯一供应商（来源人群，140万人）。主要的结果指标是从1小时到超过16小时的空腹时间段内高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、总胆固醇和甘油三酯的平均水平。在控制个体年龄差异后，采用线性回归模型估计不同禁食时间胆固醇亚类的平均水平。结果：共有209180人（女性111048人，男性98132人）被纳入本研究。总胆固醇和高密度脂蛋白胆固醇的平均水平在不同禁食时间的个体之间差异不大。结论：在社区人群中，空腹时间与血脂亚类水平无明显相关性，提示空腹监测血脂水平是不必要的。Arch Intern Med.2012; 172（22）：1707-1710。2012年11月12日在线发布。doi：10.1001/archintermed.2012.3708
Background: Although current guidelines recommend measuring lipid levels in a fasting state, recent studies suggest that nonfasting lipid profiles change minimally in response to food intake and may be superior to fasting levels in predicting adverse cardiovascular outcomes. The objective of this study was to investigate the association between fasting times and lipid levels.Methods: Cross-sectional examination of laboratory data, including fasting duration (in hours) and lipid results, was performed over a 6-month period in 2011 in a large community-based cohort. Data were obtained from Calgary Laboratory Services, Calgary, Alberta, Canada, the sole supplier of laboratory services for Calgary and surrounding areas (source population, 1.4 million persons). The main outcome measures were mean levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol, and triglycerides for fasting intervals from 1 hour to more than 16 hours. After differences in individual ages were controlled for, linear regression models were used to estimate the mean levels of cholesterol subclasses at different fasting times.Results: A total of 209 180 individuals (111 048 females and 98 132 males) were included in the study. The mean levels of total cholesterol and high-density lipoprotein cholesterol differed little among individuals with various fasting times. The mean calculated low-density lipoprotein cholesterol levels showed slightly greater variations of up to 10% among groups of patients with different fasting intervals, and the mean triglyceride levels showed variations of up to 20%.Conclusion: Fasting times showed little association with lipid subclass levels in a community-based population, which suggests that fasting for routine lipid levels is largely unnecessary. Arch Intern Med. 2012; 172(22): 1707-1710. Published online November 12, 2012. doi: 10.1001/archinternmed.2012.3708