The role of VEGF and KDR polymorphisms in moyamoya disease and collateral revascularization.
The role of VEGF and KDR polymorphisms in moyamoya disease and collateral revascularization.
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DOI：
10.1371/journal.pone.0047158
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Kim NK
中科院分区：
文献类型：
--
作者：
Park YS;Jeon YJ;Kim HS;Chae KY;Oh SH;Han IB;Kim HS;Kim WC;Kim OJ;Kim TG;Choi JU;Kim DS;Kim NK
我们进行了一项病例对照研究，以调查血管内皮生长因子（VEGF-2578，-1154，-634和936）和激酶插入结构域包含受体（KDR-604，1192和1719）多态性是否与烟雾病相关。入选韩国烟雾病患者（n =107，平均年龄，20.9±15.9岁; 66.4%为女性）和243名健康对照受试者（平均年龄，23.0±16.1岁; 56.8%为女性）。 受试者分为儿童组和成人组。在64例手术患者中，我们评估了2年后的侧支血管形成情况，并将患者分为良好（侧支血管A级）或不良（侧支血管B和C级）组。在烟雾病患者中评估了4种VEGF（−2578、−1154、−634和936）和KDR（−604、1192和1719）多态性的频率和分布，并与对照组进行了比较。在对照组和烟雾病组之间没有观察到VEGF-2578、-1154、-634和936或KDR-604、1192和1719多态性的差异。然而，我们发现− 634 CC基因型在儿童烟雾病组中发生频率较低（p = 0.040），而KDR − 604 C/1192 A/1719 T单倍型增加了儿童烟雾病的风险（p = 0.024）。 具有VEGF −634 CC基因型的患者在手术后有更好的侧支血管形成。我们的研究结果表明，VEGF − 634 G等位基因与儿童烟雾病和不良侧支血管形成相关。
We conducted a case-control study to investigate whether vascular endothelial growth factor (VEGF −2578, −1154, −634, and 936) and kinase insert domain containing receptor (KDR −604, 1192, and 1719) polymorphisms are associated with moyamoya disease. Korean patients with moyamoya disease (n = 107, mean age, 20.9±15.9 years; 66.4% female) and 243 healthy control subjects (mean age, 23.0±16.1 years; 56.8% female) were included. The subjects were divided into pediatric and adult groups. Among the 64 surgical patients, we evaluated collateral vessel formation after 2 years and divided patients into good (collateral grade A) or poor (collateral grade B and C) groups. The frequencies and distributions of four VEGF (−2578, −1154, −634, and 936) and KDR (−604, 1192, and 1719) polymorphisms were assessed from patients with moyamoya disease and compared to the control group. No differences were observed in VEGF −2578, −1154, −634, and 936 or KDR −604, 1192, and 1719 polymorphisms between the control group and moyamoya disease group. However, we found the −634CC genotype occurred less frequently in the pediatric moyamoya group (p = 0.040) whereas the KDR −604C/1192A/1719T haplotype increased the risk of pediatric moyamoya (p = 0.024). Patients with the CC genotype of VEGF −634 had better collateral vessel formation after surgery. Our results suggest that the VEGF −634G allele is associated with pediatric moyamoya disease and poor collateral vessel formation.
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