Hypometabolism and altered metabolic connectivity in patients with internet gaming disorder and alcohol use disorder
Hypometabolism and altered metabolic connectivity in patients with internet gaming disorder and alcohol use disorder
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DOI：
10.1016/j.pnpbp.2019.109680
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发表时间：
2019-12-20
影响因子：
5.6
通讯作者：
Choi, Jung-Seok
中科院分区：
文献类型：
--
作者：
Kim, Heejung;Kim, Yu Kyeong;Choi, Jung-Seok
网络游戏障碍（IGD）作为一种成瘾行为已成为越来越受到关注的主题，并已与物质/非物质相关成瘾进行了比较。虽然IGD表现出临床损害和社会功能障碍，但IGD的神经生物学改变尚未明确阐明。我们使用F-18-氟脱氧葡萄糖PET研究了年轻男性[36例IGD患者，26例酒精使用障碍（AUD）患者和39例健康对照（HC）]的葡萄糖代谢和代谢连接的差异。与HC相比，IGD显示前扣带回皮质（ACC），颞叶，额叶，顶叶和纹状体代谢减少，AUD显示枕叶代谢减少，颞叶和顶叶小叶。此外，IGD表现出负相关之间的ACC和游戏时间和之间的眶额皮质和冲动。此外，IGD的颞叶和边缘区域之间以及运动区和枕叶区域之间的代谢连接性较低。AUD显示眶额区和顶叶区之间以及躯体感觉区或顶叶区和颞叶区之间的代谢连接性更强，但额-纹状体区或额-边缘区的代谢连接性较低。我们的研究结果提供了证据表明，IGD的低代谢和代谢连接改变可能与长期游戏和冲动/动机状态功能障碍引起的感觉功能异常有关。
Internet gaming disorder (IGD) has become the subject of growing concern as an addictive behavior and has been compared with substance/non-substance-related addiction. Although IGD show clinical impairments and social dysfunction, neurobiological alterations in IGD have not been clearly elucidated. We used F-18-fluorodeoxyglucose PET to investigate differences in glucose metabolism and metabolic connectivity in young men [thirty-six patients with IGD, twenty-six patients with alcohol use disorder (AUD) and thirty-nine healthy controls (HC)].Compared with the HC, IGD showed hypometabolism in the anterior cingulate cortex (ACC), temporal, frontal, parietal and striatum and AUD exhibited hypometabolism in the occipital, temporal and parietal lobule. Furthermore, IGD showed negative correlations between the ACC and game duration and between the orbitofrontal cortex and impulsivity. Also, IGD had lower metabolic connectivity between temporal and limbic regions and between the motor area and occipital region. And AUD showed greater metabolic connectivity between the orbitofrontal and parietal regions, and between the somatosensory or parietal and temporal regions, but lower metabolic connectivity in the fronto-striatal or fronto-limbic regions. Our results provide evidences that hypometabolism and altered metabolic connectivity in IGD might be related to the abnormal sensory function by longtime gaming and dysfunction of impulsive/motivational states.