Effect of three retinoids on tracheal carcinogenesis with N-methyl-N-nitrosourea in hamsters.
Effect of three retinoids on tracheal carcinogenesis with N-methyl-N-nitrosourea in hamsters.
复制标题
三种视黄醇对仓鼠 N-甲基-N-亚硝基脲气管癌发生的影响。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
R. Donahoe
中科院分区：
文献类型：
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作者：
S. Stinson;G. Reznik;R. Donahoe
雄性叙利亚金黄地鼠用特殊导管每周12次气管内暴露于0.5%N-甲基-N-亚硝脲。暴露后，动物被随机分成4组，每组63只，分别饲喂含12 0 mg 13-顺式维甲酸(CRA)/kg、327 mg乙基维甲酰胺(ER)/kg和343 mg N-(2-羟乙基)维甲酰胺(HR)/kg的试验粉或饲料，6个月后处死。观察到的气管上皮性肿瘤的发病率(No.荷瘤动物数量/总数量动物)分别为10/63(实验餐)、22/61(CRA)、24/63(ER)和17/62(HR)。癌症发病率(第1位)。荷瘤动物数量/总数量动物)分别为4/63(实验餐)、12/61(CRA)、12/63(ER)和11/62(HR)。与喂食实验餐的组相比，喂食HR的组的体重减轻和死亡率显著，但在其他维甲酸治疗组中没有。
Male Syrian golden hamsters received 12 weekly intratracheal exposures to 0.5% N-methyl-N-nitrosourea with a special catheter. Following exposures, animals were randomized into 4 groups of 63 hamsters and placed on diets of lab meal or meal with 120 mg 13-cis-retinoid acid (CRA)/kg, 327 mg ethyl retinamide (ER)/kg, or 343 mg N-(2-hydroxyethyl)retinamide (HR)/kg for 6 months at which time all hamsters were killed. The observed incidences of tracheal epithelial neoplasms (No. of animals with tumors/total No. of animals) were 10/63 (lab meal), 22/61 (CRA), 24/63 (ER), and 17/62 (HR). The incidence of carcinomas (No. of animals with tumors/total No. of animals) were 4/63 (lab meal), 12/61 (CRA), 12/63 (ER), and 11/62 (HR). The weight loss and mortality relative to those in the group fed the lab meal were significantly in the group fed HR but not in the other retinoid-treated groups.