Hypoxia inducible factor-1α and vascular endothelial growth factor expression are associated with a poor prognosis in patients with nasopharyngeal carcinoma receiving radiotherapy with carbogen and nicotinamide
Hypoxia inducible factor-1α and vascular endothelial growth factor expression are associated with a poor prognosis in patients with nasopharyngeal carcinoma receiving radiotherapy with carbogen and nicotinamide
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DOI：
10.1016/j.clon.2008.07.001
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发表时间：
2008-10-01
影响因子：
3.4
通讯作者：
Feng Yan
中科院分区：
文献类型：
--
作者：
Lu Xueguan;Wang Xiaoshen;Feng Yan
目的：缺氧降低肿瘤放射敏感性，缺氧诱导因子-1 α（HIF-1 α）在此过程中起重要作用。该研究的目的是评估HIF-1 α的预后影响。鼻咽癌患者接受低氧调节治疗后放射治疗前后血清VEGF水平的变化材料和方法：采用免疫组化方法检测59例接受常规放疗联合卡波姆和烟酰胺治疗的鼻咽癌患者的鼻咽活检组织中HIF-1 α和VEGF的表达。HIF-1 α与VEGF表达呈显著正相关（P = 0.003）。HIF-1 α、VEGF表达水平与肿瘤分期、淋巴结分期或临床分期之间无相关性。Kaplan-Meier曲线显示HIF-1 α和VEGF阳性表达与较高的远处转移、较差的总体生存期和无病生存期相关，而HIF-1 α和VEGF表达水平对局部复发无影响。多因素分析未能证实HIF-1 α或VEGF和转移，无病或总survivs.Conclusions之间的任何关联：这些结果表明，缺氧相关标志物（HIF-1 α和VEGF）的表达可能有预后意义的鼻咽癌患者接受放射治疗加carbogen和nicotinamide，但需要进一步研究。
Aims: Hypoxia reduces tumour radiosensitivity and hypoxia inducible factor-1 alpha (HIF-1 alpha) plays an important role in this process. The aim of the study was to assess the prognostic impact of HIF-1 alpha. and vascular endothelial growth factor (VEGF) in patients with nasopharyngeal carcinoma who received radiation with hypoxia-modifying therapy (carbogen plus nicotinamide).Materials and methods: The immunohistochemical expression of HIF-1 alpha and VEGF was evaluated in nasopharyngeal carcinoma biopsies from 59 patients who received conventional radiotherapy combined with carbogen and nicotinamide.Results: A significant positive association was found between HIF-1 alpha and VEGF expression (P = 0.003). There was no association found between the level of HIF-1 alpha, VEGF expression and tumour stage, nodal stage, or clinical stage. Kaplan-Meier plots showed that positive HIF-1 alpha and VEGF expression were associated with a higher distant metastasis, a worse overall and disease-free survival, and the level of HIF-1 alpha and VEGF expression had no effect on locoregional recurrence. The multivariate analysis failed to confirm any association between HIF-1 alpha or VEGF and metastasis, disease-free or overall survival.Conclusions: These results suggest that the expression of hypoxia-associated markers (HIF-1 alpha and VEGF) may have prognostic significance in patients with nasopharyngeal carcinoma who receive radiation plus carbogen and nicotinamide, but further study is needed.