Clinical and MRI features of Japanese patients with multiple sclerosis positive for NMO-IgG
Clinical and MRI features of Japanese patients with multiple sclerosis positive for NMO-IgG
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DOI：
10.1136/jnnp.2005.080390
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发表时间：
2006-09-01
影响因子：
11
通讯作者：
Itoyama, Y.
中科院分区：
文献类型：
--
作者：
Nakashima, I.;Fujihara, K.;Itoyama, Y.
本研究探讨了日本多发性硬化患者的NMO（视神经肌萎缩症）-IgG血清学状态与临床和MRI特征之间的关系。在35名诊断为多发性硬化症的日本患者中检测了血清NMO-IgG，其中包括19名视脊髓型多发性硬化症（OSMS），3名脊髓型多发性硬化症（SMS）和13名影响大脑的常规型多发性硬化症（CMS）。NMO-IgG阳性14例，其中OSMS 12例，CMS 2例。在这些患者中，纵向广泛（。与NMO-IgG阴性的OSMS相比，在至少一只眼睛中（93%对57%）和永久性完全失明（无光感）（50%对0%）中的脊髓病变是值得注意的特征。两名患有CMS与NMO-IgG的患者有不寻常的脑部病变，但在其他方面有提示OSMS的特征。在超过一半的OSMS患者和一些CMS患者中检测到NMO-IgG。这种新发现的血清自身抗体与纵向广泛的脊髓病变和完全失明明显相关，提示严重的视脊髓疾病。
This study investigates the relation between the serological status of NMO ( neuromyelitis optica)-IgG and the clinical and MRI features in Japanese patients with multiple sclerosis. Serum NMO-IgG was tested in 35 Japanese patients diagnosed with multiple sclerosis, including 19 with the optic-spinal form of multiple sclerosis (OSMS), three with the spinal form of multiple sclerosis (SMS), and 13 with the conventional form of multiple sclerosis (CMS), which affects the brain. NMO-IgG was detected in 14 patients, 12 with OSMS and 2 with CMS. In these patients, longitudinally extensive (. 3 vertebral segments) spinal cord lesions (93% v 57%) and permanent, complete blindness ( no perception of light) in at least one eye (50% v 0%) were the noticeable features as compared with NMO-IgG-negative OSMS. The two patients having CMS with NMO-IgG had unusual brain lesions, but in other respects had features suggesting OSMS. NMO-IgG was detected in more than half the number of patients with OSMS and in some patients with CMS. This newly discovered serum autoantibody was markedly associated with longitudinally extensive spinal cord lesions and with complete blindness, suggesting severe optic - spinal disease.