Phenazine-1-carboxylic acid derivatives: design, synthesis and biological evaluation against Rhizoctonia solani Kuhn.
Phenazine-1-carboxylic acid derivatives: design, synthesis and biological evaluation against Rhizoctonia solani Kuhn.
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DOI：
10.1016/j.bmcl.2010.10.050
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发表时间：
2010-12
影响因子：
2.7
通讯作者：
Long Ye;Hongyan Zhang;Hong Xu;Q. Zou;Chao Cheng;Dexian Dong;Yuquan Xu;Rongxiu Li
中科院分区：
文献类型：
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作者：
Long Ye;Hongyan Zhang;Hong Xu;Q. Zou;Chao Cheng;Dexian Dong;Yuquan Xu;Rongxiu Li
立枯丝核菌（RhizoctoniasolaniKuhn）是引起水稻纹枯病的病原体，其导致水稻和近50种其它作物的显著减产。为了开发新型杀菌剂，设计合成了一系列结构不同的吩嗪-1-羧酸衍生物2a、2b、2c、2d、2 e、2f、2g、2 h、2 i、2 j和2k，并对其抑菌活性进行了评价。其中活性最高的两个化合物2 i和2 j被选为先导化合物，用于进一步的抗真菌研究。
Rhizoctonia solani Kuhn is the pathogen that causes sheath blight and results in significant yield reduction in rice and in nearly 50 other crops. In order to develop a new fungicide effective against this pathogen, a series of structurally diverse phenazine-1-carboxylic acid derivatives, 2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h, 2i, 2j, and 2k, were designed, synthesized and evaluated for their antifungal activity. The two most active compounds 2i and 2j were selected as lead compounds for further antifungal research.