Disease-specific diagnosis of coinfecting tickborne zoonoses: Babesiosis, human granulocytic ehrlichiosis, and Lyme disease
Disease-specific diagnosis of coinfecting tickborne zoonoses: Babesiosis, human granulocytic ehrlichiosis, and Lyme disease
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DOI：
10.1086/339813
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发表时间：
2002-05-01
影响因子：
11.8
通讯作者：
Spielman, A
中科院分区：
文献类型：
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作者：
Krause, PJ;McKay, K;Spielman, A
为了确定是否有一组独特的临床和实验室表现特征某些主要鹿蜱传播的人类病原体在北美，我们比较了症状，短期并发症，和实验室检查结果的新英格兰居民谁生病，由于大于或等于1这些病原体。患者在出现莱姆病、人类巴贝虫病或人类粒细胞埃里希体病（HGE）症状后，完成了一份统一结构的问卷，并提交了血液样本进行血清学和聚合酶链反应（PCR）检测。全血细胞计数与薄血涂片，PCR和免疫球蛋白M抗体测试有助于区分这些疾病的急性表现。医生应考虑使用旨在诊断巴贝斯虫病和HGE的莱姆病患者谁经历了长期的流感样疾病，未能响应适当的抗疏螺旋体治疗。
To determine whether a unique group of clinical and laboratory manifestations characterize certain major deer tick-transmitted human pathogens in North America, we compared the symptoms, short-term complications, and laboratory test results of New England residents who became ill due to greater than or equal to1 of these pathogens. Patients completed a uniformly structured questionnaire and submitted blood samples for serologic and polymerase chain reaction (PCR) testing after developing symptoms of Lyme disease, human babesiosis, or human granulocytic ehrlichiosis (HGE). Complete blood count with thin blood smear, PCR, and immunoglobulin M antibody tests helped differentiate the acute manifestations of these diseases. Physicians should consider use of tests designed to diagnose babesiosis and HGE in patients with Lyme disease who experience a prolonged flulike illness that fails to respond to appropriate antiborrelial therapy.