Positional information and reaction-diffusion: two big ideas in developmental biology combine
Positional information and reaction-diffusion: two big ideas in developmental biology combine
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DOI：
10.1242/dev.114991
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发表时间：
2015-04-01
期刊：
影响因子：
4.6
通讯作者：
Sharpe, James
中科院分区：
文献类型：
--
作者：
Green, Jeremy B. A.;Sharpe, James
生物学中最基本的问题之一是生物模式：生物体的结构和形状是如何产生的？毫无疑问，这一领域最有影响力的两个思想是阿兰·图灵的“反应-扩散”和刘易斯·沃尔珀特的“位置信息”。关于这两个概念已经写了很多，但仍然存在一些混乱，特别是关于它们之间的关系。在这里，我们解决这种关系，并提出了三个不同的方式，这两个想法一起工作，以塑造生物形式的方案。
One of the most fundamental questions in biology is that of biological pattern: how do the structures and shapes of organisms arise? Undoubtedly, the two most influential ideas in this area are those of Alan Turing's 'reaction-diffusion' and Lewis Wolpert's 'positional information'. Much has been written about these two concepts but some confusion still remains, in particular about the relationship between them. Here, we address this relationship and propose a scheme of three distinct ways in which these two ideas work together to shape biological form.