Hydrocarbon oxidation vs C-C bond-forming approaches for efficient syntheses of oxygenated molecules
Hydrocarbon oxidation vs C-C bond-forming approaches for efficient syntheses of oxygenated molecules
复制标题
DOI：
10.1021/ol047800p
复制
发表时间：
2005-01-20
期刊：
影响因子：
5.2
通讯作者：
White, MC
中科院分区：
文献类型：
--
作者：
Fraunhoffer, KJ;Bachovchin, DA;White, MC
碳氢化合物氧化方法已应用于几种线性(E)-烯丙醇的构建，这些醇在天然产物和天然产物类分子的合成中用作中间体。在最初的合成中…这些中间体是用标准的wittig型烯烃方法构建的。我们在这里报道，围绕碳氢化合物氧化方法设计的相同中间体的路线在官能团操作（fgm）的总数和总体步骤以及总体收率方面都更有效。
A hydrocarbon oxidation approach has been applied to the construction of several linear (E)-allylic alcohols that have served as intermediates in the synthesis of natural products and natural product-like molecules. In the original syntheses.. these intermediates were constructed using a standard Wittig-type olefination approach. We report here that routes to these same intermediates designed around a hydrocarbon oxidation approach are more efficient both in the total number of functional group manipulations (FGMs) and overall steps, as well as in the overall yield.