Modulation of cardiac growth and development by HOP, an unusual homeodomain protein
Modulation of cardiac growth and development by HOP, an unusual homeodomain protein
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DOI：
10.1016/s0092-8674(02)00933-9
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发表时间：
2002-09-20
期刊：
影响因子：
64.5
通讯作者：
Olson, EN
中科院分区：
文献类型：
--
作者：
Shin, CH;Liu, ZP;Olson, EN
我们发现了一种不寻常的同源结构域蛋白，称为HOP，它只由一个同源结构域组成。HOP在发育中的心脏中高度表达，其中其表达依赖于心脏限制性同源结构域蛋白Nkx2.5。HOP不结合DNA，并作为血清反应因子（SRF）的拮抗剂，其调节增殖和肌生成的相反过程。HOP无效等位基因纯合的小鼠分离成两个表型类别，其特征在于心肌细胞过多或不足。我们认为HOP在心脏发育过程中调节SRF活性，其缺失导致心肌细胞增殖和分化之间的不平衡，从而导致心脏形态发生异常。
We have discovered an unusual homeodomain protein, called HOP, which is comprised simply of a homeodomain. HOP is highly expressed in the developing heart where its expression is dependent on the cardiac-restricted homeodomain protein Nkx2.5. HOP does not bind DNA and acts as an antagonist of serum response factor (SRF), which regulates the opposing processes of proliferation and myogenesis. Mice homozygous for a HOP null allele segregate into two phenotypic classes characterized by an excess or deficiency of cardiac myocytes. We propose that HOP modulates SRF activity during heart development; its absence results in an imbalance between cardiomyocyte proliferation and differentiation with consequent abnormalities in cardiac morphogenesis.