The Leishmania antigen-specific pro-inflammatory response in cutaneous leishmaniasis is linked to disease progression but not to the therapeutic failure of pentavalent antimonials.
The Leishmania antigen-specific pro-inflammatory response in cutaneous leishmaniasis is linked to disease progression but not to the therapeutic failure of pentavalent antimonials.
复制标题
DOI：
10.1016/j.micinf.2021.104866
复制
发表时间：
2021-11
影响因子：
5.8
通讯作者：
Carvalho LP
中科院分区：
文献类型：
--
作者：
Franca M;Guimarães LH;Nascimento MT;Rocha PN;Carvalho LP
皮肤利什曼病患者体内高水平的促炎细胞因子与组织损伤和溃疡发展相关。我们发现，在病程较长的个体中，对可溶性利什曼原虫抗原应答的外周血单核细胞上清液中TNF和IL-1β水平较高。此外，L.治疗前疾病进展时间较长的巴西感染患者在治疗开始后的治愈时间较短。促炎细胞因子IL-6、TNF和IL-1-β的水平与患者对五价锑治疗的反应之间未发现相关性。我们的数据表明，虽然利什曼原虫抗原特异性促炎细胞因子的研究可能会导致溃疡的发展，他们不影响皮肤利什曼病患者的治疗失败。
High levels of pro-inflammatory cytokines in cutaneous leishmaniasis patients are associated with tissue damage and ulcer development. We found higher levels of TNF and IL-1β in peripheral blood mononuclear cell supernatants in response to soluble Leishmania antigen in individuals with a longer duration of disease. In addition, L. braziliensis-infected patients with a longer disease progression before treatment presented a shorter time to cure after treatment onset. No associations were found between the levels of the pro-inflammatory cytokines IL-6, TNF and IL-1-β and patients’ response to pentavalent antimony treatment. Our data suggest that while the Leishmania antigen-specific pro-inflammatory cytokines investigated may lead to ulcer development, they do not influence therapeutic failure in cutaneous leishmaniasis patients.
登录
查看更多内容
影响因子：
3.7
作者：
Ostyn B;Hasker E;Dorlo TP;Rijal S;Sundar S;Dujardin JC;Boelaert M
通讯作者：
Boelaert M
影响因子：
3.8
作者：
del Mar Castro, Maria;Cossio, Alexandra;Osorio, Lyda
通讯作者：
Osorio, Lyda
影响因子：
11.8
作者：
Machado, Paulo R. L.;Lessa, Helio;Carvalho, Edgar M.
通讯作者：
Carvalho, Edgar M.
影响因子：
6.7
作者：
Novais, Fernanda O.;Carvalho, Augusto M.;Scott, Phillip
通讯作者：
Scott, Phillip
影响因子：
6.4
作者：
Campos, Tais M.;Novais, Fernanda O.;Carvalho, Lucas P.
通讯作者：
Carvalho, Lucas P.