Fundamental steps in experimental design for animal studies
Fundamental steps in experimental design for animal studies
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DOI：
10.1590/s0102-86502005000100002
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发表时间：
2005-02-01
影响因子：
1.1
通讯作者：
Aguilar-Nascimento, José Eduardo de
中科院分区：
文献类型：
--
作者：
Aguilar-Nascimento, José Eduardo de
动物研究继续在科学发展中发挥着至关重要的作用。这篇综述的目的是为新的研究者提供实验设计中所涉及的重要步骤的概述，并提出一些与此过程相关的实用信息。研究者应遵守伦理程序，严格遵循科学方法。目标和精心制定的假设都是必要的和实用的。在这方面，鼓励进行深入的文献检索，并请有经验的统计人员协助。随机化、设盲和尽量减少变异的必要性进行了讨论和推荐。选择良好的对照组和采用试点研究是有益的。最后，提出了有待进一步回答的新问题。
Animal studies continue to have a vital role in science development. The aim of this review is to provide to new investigators an overview of the important steps involved in experimental designs and also to suggest some practical information that is commonly associated with this process. Investigators should adhere to the ethical procedure and follow strictly the scientific method. Both the aims and well-formulated hypothesis are essential and practical. In this regard a profound literature search and the aid of an experienced statistician is encouraged. The need of randomization, blinding, and attempting to minimize variation is discussed and recommended. The choosing of good control groups and the employment of pilot studies are useful. Finally, the formulation of new questions to be further responded is expected.