Distribution of serum C-reactive protein and its association with atherosclerotic risk factors in a Japanese population - Jichi Medical School Cohort Study
Distribution of serum C-reactive protein and its association with atherosclerotic risk factors in a Japanese population - Jichi Medical School Cohort Study
复制标题
DOI：
10.1093/aje/153.12.1183
复制
发表时间：
2001-06-15
影响因子：
5
通讯作者：
Kajii, E
中科院分区：
文献类型：
--
作者：
Yamada, S;Gotoh, T;Kajii, E
1992 年至 1995 年间，研究人员在大量日本人群中研究了血清 C 反应蛋白 (CRP) 水平的分布及其与年龄、性别和动脉粥样硬化危险因素的关系。研究对象包括 30 岁及以上的 2,275 名男性和 3,832 名女性。 CRP通过比浊法测量。 CRP 的分布高度偏向于低于先前研究的水平，并且似乎是两条单独的分布曲线的组合。 CRP随着年龄的增长而增加具有统计学意义，并且男性的CRP水平高于女性。目前吸烟的男性的 CRP 水平高于不吸烟的男性。年龄、收缩压、舒张压、甘油三酯、纤维蛋白原和体重指数在男女中均与 CRP 呈正相关，而总胆固醇和血糖仅在女性中呈正相关。高密度脂蛋白胆固醇在两性中均呈负相关。多元逻辑回归分析显示，性别、年龄、收缩压、高密度脂蛋白胆固醇、甘油三酯、纤维蛋白原和体重指数是显着的自变量。总之，尽管 CRP 水平与其他动脉粥样硬化危险因素相关，与西方人类似，但日本人的 CRP 分布与西方人有很大不同。
The distribution of serum C-reactive protein (CRP) levels and their association with age, sex, and atherosclerotic risk factors were studied in a large Japanese population between 1992 and 1995, The subjects consisted of 2,275 males and 3,832 females aged 30 years and over. CRP was measured by nephelometry. The distribution of CRP was highly skewed toward a lower level than that of previous studies and seemed to be a combination of two separate distribution curves. The increase in CRP with age was statistically significant, and males had higher CRP levels than did females. Males who were current smokers had higher CRP levels than did nonsmokers. Age, systolic blood pressure, diastolic blood pressure, triglycerides, fibrinogen, and body mass index were all positively associated with CRP in both sexes, while total cholesterol and blood glucose were positively related in females only. High density lipoprotein cholesterol was inversely related in both sexes. Multiple logistic regression analysis showed that sex, age, systolic pressure, high density lipoprotein cholesterol, triglycerides, fibrinogen, and body mass index were significant independent variables. In conclusion, the distribution of CRP among the Japanese was quite different from that among Westerners, although CRP levels correlated with other atherosclerotic risk factors, similar to those in Westerners.