TOPOGRAPHICAL VARIATION OF THE HUMAN PRIMARY CORTICES - IMPLICATIONS FOR NEUROIMAGING, BRAIN MAPPING, AND NEUROBIOLOGY
TOPOGRAPHICAL VARIATION OF THE HUMAN PRIMARY CORTICES - IMPLICATIONS FOR NEUROIMAGING, BRAIN MAPPING, AND NEUROBIOLOGY
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DOI：
10.1093/cercor/3.4.313
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发表时间：
1993-07-01
期刊：
影响因子：
3.7
通讯作者：
GALABURDA, AM
中科院分区：
文献类型：
--
作者：
RADEMACHER, J;CAVINESS, VS;GALABURDA, AM
从20个人脑半球（10个脑）的连续组织切片中重建了“初级"细胞结构新皮质区17、41、3b和4（Brodmann区）与显著地形标志的关系。这些架构领域中的每一个都被发现与一组框架解剖标志（特别是脑回、脑裂和脑沟）具有特征性关系，这些特征性关系可以很容易地通过MRI来定义。两类变异的特点，至少在某种程度上，每个领域。1级变异性，是不可预测的，从可见的地标是典型的极地和楔和舌外的钙分布的字段17和分布的字段4上的旁中央小叶。第2类变异性，是密切可预测的，从可见的地标，被认为是在显着的个体间或半球间的变化，在大小或形状的一个领域，并被发现是突出的所有四个领域。由于2级变异性的突出性，与参考标准或理想化大脑的模板或基于立体定向坐标的系统相比，直接参考构建这些视野的标志可能是功能标测的更可靠基础。
The relationships of the ''primary'' cytoarchitectonic neocortical fields, 17, 41, 3b, and 4 (Brodmann areas), to salient topographic landmarks have been reconstructed from serial histological sections in 20 human cerebral hemispheres (10 brains). Each of these architectonic fields is found to bear a characteristic relationship to a set of enframing anatomic landmarks, in particular, gyri, fissures, and sulci, that can be readily defined by MRI. Two classes of variability were found characteristic, at least to some extent, of each of the fields. Class 1 variability-variability that is not predictable from visible landmarks-was typical of the polar and for the cuneal and lingual extracalcarine distributions of field 17 and the distribution of field 4 upon the paracentral lobule. Class 2 variability-variability that is closely predictable from visible landmarks-is seen in the marked interindividual or interhemispheric variation in size or shape of a field and was found to be prominent for all four fields. Because of the prominence of class 2 variability, direct reference to the landmarks that frame these fields may be expected to be a more reliable basis for functional mapping than reference to a template or stereotactic coordinate-based system of reference to a standard or idealized brain.