Treatment of menstrual migraine by oestradiol implants.
Treatment of menstrual migraine by oestradiol implants.
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通过雌二醇植入物治疗月经性偏头痛。
DOI：
10.1136/jnnp.46.11.1044
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Jww Studd
中科院分区：
文献类型：
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作者：
AL Maggs;K. Zilkha;Jww Studd
在长达5年的时间里，24例经期偏头痛患者通过皮下植入雌二醇来抑制卵巢周期性活动，并在血液中产生恒定的雌二醇水平。23例患者的病情得到改善，20例（83%）完全或几乎完全消除头痛。周期性口服孕激素诱导月经规律。这种治疗没有产生任何问题。研究结果支持了这样一个概念，即卵巢周期的黄体晚期和月经期雌激素的减少是月经期偏头痛的重要诱发因素，可以通过抑制与卵巢周期相关的激素波动来预防这种发作。
The suppression of cyclical ovarian activity and the creation of constant oestradiol levels in blood by subcutaneous oestradiol implants has been used to treat 24 patients with menstrual migraine for up to five years. Twenty-three patients improved with treatment, 20 (83%) became completely or almost completely headache-free. Regular monthly periods were induced with cyclical oral progestogens. The treatment was not associated with any problems. The results support the concept that oestrogen withdrawal in the late luteal and menstrual phases of the ovarian cycle is the important precipitating factor in menstrual migraine, and such attacks can be prevented by suppressing the hormonal fluctuations associated with the ovarian cycle.