Serial Scans in Healthy Volunteers Following Intravenous Administration of Gadoteridol: Time Course of Contrast Enhancement in Various Cranial Fluid Spaces
Serial Scans in Healthy Volunteers Following Intravenous Administration of Gadoteridol: Time Course of Contrast Enhancement in Various Cranial Fluid Spaces
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DOI：
10.2463/mrms.2013-0056
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发表时间：
2014-01-01
影响因子：
3
通讯作者：
Sakurai, Yasuo
中科院分区：
文献类型：
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作者：
Naganawa, Shinji;Suzuki, Kojiro;Sakurai, Yasuo
目的：据报道，重 T-2 加权、3 维、液体衰减反转恢复 (hT(2)W-3D-FLAIR) 成像可检测眼前节 (AES)、蛛网膜下腔 (SAS) 和迷路外淋巴以及内听道 (IAC) 脑脊液 (CSF) 中的低浓度钆基造影剂 (GBCM)内耳疾病患者静脉注射单剂量 (IV-SD-GBCM) 后 4 小时。为了阐明健康志愿者对比度增强的时间过程，我们在 IV-SD-GBCM 后连续获得 hT(2)W-3D-FLAM。 材料和方法：我们在 6 名健康志愿者中在 IV-SD-GBCM 之前和之后 0.5、1.5、3、4.5 和 6 小时获得 hT2W-3D-FLAIR，并测量视神经周围的 AES、SAS (SAS-ON)、梅克尔洞中的 SAS (SAS-MC)、脑桥实质、IAC 中的脑脊液 (CSF-IAC)、环池中的脑脊液 (CSF-AC)、侧脑室中的脑脊液 (CSF-LV)、迷路中的外淋巴 (PL) 和内淋巴 (EL)。然后，我们使用方差分析 (ANOVA) 比较了所有时间点的平均值。结果：IV-SD-GBCM 后，我们观察到脑桥实质、CSF-LV 或 EL 中的信号强度没有变化，而所有其他结构中的信号强度均显着增强。在 SAS-ON 和 PL 中，最大增强出现在 IV-SD-GBCM 后 4.5 小时，在 AES 和 SAS-MC 中，出现在 1.5 小时，在 CSF-IAC 和 CSF-AC 中出现在 3 小时。结论：在健康志愿者中，hT2W-3D-FLAIR 可以在 AES、SAS-ON、SAS-MC、PL、CSF-IAC 和 CSF-AC 中检测到对比度增强IV-SD-GBCM 后。最大增强的时间因地点而异。这些数据可以作为未来临床研究的基础知识。
Purpose: Heavily T-2-weighted, 3-dimensional, fluid-attenuated inversion recovery (hT(2)W-3D-FLAIR) imaging has been reported to detect low concentrations of gadolinium-based contrast media (GBCM) in the anterior eye segment (AES), subarachnoid space (SAS), and labyrinthine perilymph as well as in the cerebrospinal fluid (CSF) of the internal auditory canal (IAC) 4 hours after intravenous administration of a single dose (IV-SD-GBCM) in patients with inner ear disorders. To elucidate the time course of contrast enhancement in healthy volunteers, we obtained hT(2)W-3D-FLAM serially after IV-SD-GBCM.Materials and Methods: We obtained hT2W-3D-FLAIR before and 0.5, 1.5, 3, 4.5 and 6 hours after IV-SD-GBCM in 6 healthy volunteers and measured signal intensity of the AES, SAS surrounding the optic nerve (SAS-ON), SAS in Meckel's cave (SAS-MC), pontine parenchyma, CSF in the IAC (CSF-IAC), CSF in the ambient cistern (CSF-AC), CSF in the lateral ventricles (CSF-LV), perilymph (PL), and endolymph (EL) in the labyrinth. We then compared averaged values among all time points using analysis of variance (ANOVA).Results: After IV-SD-GBCM, we observed no change in signal intensity in the pontine parenchyma, CSF-LV, or EL and significant enhancement in all other structures. Maximum enhancement was most frequent at 4.5 hours after IV-SD-GBCM in the SAS-ON and PL, at 1.5 hours in the AES and SAS-MC, and at 3 hours in the CSF-IAC and CSF-AC.Conclusions: Contrast enhancement can be detected by hT2W-3D-FLAIR in the AES, SAS-ON, SAS-MC, PL, CSF-IAC, and CSF-AC in healthy volunteers after IV-SD-GBCM. Timing of maximum enhancement differed among locations. These data might serve as basic knowledge for future clinical research.