Genetic causation of neointimal hyperplasia in hemodialysis vascular access dysfunction.
Genetic causation of neointimal hyperplasia in hemodialysis vascular access dysfunction.
复制标题
血液透析血管通道功能障碍中新内膜增生的遗传因果。
DOI：
10.1111/j.1525-139x.2011.00967.x
复制
发表时间：
2012-01
影响因子：
1.6
通讯作者：
Wadehra D
中科院分区：
文献类型：
--
作者：
Lee T;Wadehra D
新生内膜增生导致的静脉狭窄是血液透析血管通路失败的主要原因。遗传因素已被证明与一般人群中的心血管疾病（CVD）和外周血管疾病（PVD）相关。遗传因素也可能通过影响导致炎症、内皮功能、氧化应激和血管平滑肌增殖的途径，在血管通路狭窄和新生内膜增生的发展中发挥重要作用。本文将讨论遗传学在理解血液透析血管通路功能障碍和其他类似的新生内膜增生发展的疾病过程中的作用，如冠状动脉疾病和外周血管疾病。
The major cause of hemodialysis vascular access failure is venous stenosis resulting from neointimal hyperplasia. Genetic factors have been shown to be associated with cardiovascular disease (CVD) and peripheral vascular disease (PVD) in the general population. Genetic factors may also play an important role in vascular access stenosis and development of neointimal hyperplasia by affecting pathways that lead to inflammation, endothelial function, oxidative stress, and vascular smooth muscle proliferation. This review will discuss the role of genetics in understanding neointimal hyperplasia development in hemodialysis vascular access dysfunction and other disease processes with similar neointimal hyperplasia development such coronary artery disease and peripheral vascular disease.