Baz, Par-6 and aPKC are not required for axon or dendrite specification in Drosophila
Baz, Par-6 and aPKC are not required for axon or dendrite specification in Drosophila
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DOI：
10.1038/nn1346
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发表时间：
2004-12-01
影响因子：
25
通讯作者：
Doe, CQ
中科院分区：
文献类型：
--
作者：
Rolls, MM;Doe, CQ
Par-3/Baz、Par-6和aPKC是进化上保守的细胞极性调节因子，过表达实验表明它们是脊椎动物海马神经元中的轴突决定因子。在这里，我们研究了它们的突变和过表达的果蝇表型。我们发现突变体神经元具有正常的轴突和树突形态，并在变态中正确地重塑轴突，并且过表达不影响轴突或树突的特化。因此，Baz/Par-6/aPKC不是果蝇轴突特化所必需的。
Par-3/Baz, Par-6, and aPKC are evolutionarily conserved regulators of cell polarity, and overexpression experiments implicate them as axon determinants in vertebrate hippocampal neurons. Here we examined their mutant and overexpression phenotypes in Drosophila melanogaster. We found that mutants neurons had normal axon and dendrite morphology and remodeled axons correctly in metamorphosis, and that overexpression did not affect axon or dendrite specification. Baz/Par-6/aPKC are therefore not essential for axon specification in Drosophila.