Classification, Clinical Features, and Molecular Genetic Models
Classification, Clinical Features, and Molecular Genetic Models
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DOI：
10.1007/978-1-4419-1472-9_1
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Nance, Melonie
中科院分区：
文献类型：
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作者：
Koch, Wayne M.;Nance, Melonie
上呼吸消化道鳞状细胞癌（头颈部鳞状细胞癌，HNSCC）通常被认为是一种基于起源细胞（粘膜上皮）和组织学特征的单一疾病。然而，独特的表型模式和基因型相关性越来越多地表明，它可能更准确地认为是由不同的实体。这些观察结果是在更传统的肿瘤分类范例的背景下发展的，这些肿瘤分类范例是基于已确立的参数，如原发性肿瘤解剖部位、分期和组织学特征。总之，临床医生寻求使用新的和传统的肿瘤特征来分类肿瘤，预测其潜在的临床过程，并选择适当的策略进行检测和治疗。
Squamous cell carcinoma of the upper aerodigestive tract (head and neck squamous cell carcinoma, HNSCC) is often considered to be a single disease based on the cell of origin (mucosal epithelium) and histologic features. However, distinctive phenotypic patterns and genotypic correlates increasingly suggest that it might be more accurately thought of as consisting of different entities. These observations have been evolving in the context of the more traditional paradigms of tumor classification based on well established parameters such as primary tumor anatomical site, stage, and histologic features. Taken together, clinicians seek to use new and traditional tumor features to categorize tumors, predict their potential clinical course, and select appropriate strategies for their detection and treatment.