The functional diversity of protein lysine methylation.
The functional diversity of protein lysine methylation.
复制标题
DOI：
10.1002/msb.134974
复制
发表时间：
2014-04-08
影响因子：
9.9
通讯作者：
Couture, Jean-Francois
中科院分区：
文献类型：
--
作者：
Lanouette, Sylvain;Mongeon, Vanessa;Figeys, Daniel;Couture, Jean-Francois
翻译后修饰（PTM）的大规模表征，如磷酸化，乙酰化和泛素化，突出了它们在调节无数信号事件中的重要性。虽然高通量技术极大地帮助了这些PTM修饰的蛋白质的编目，但赖氨酸甲基化蛋白质的鉴定，涉及将一个，两个或三个甲基转移到赖氨酸侧链的ε-胺的PTM，已经落后。虽然最初的发现集中在组蛋白的甲基化，但最近有几项研究发现了新的非组蛋白赖氨酸甲基化蛋白。这篇评论提供了迄今为止报道的所有赖氨酸甲基化位点的汇编。我们还提出了关键的例子显示赖氨酸甲基化的影响，并讨论了这个重要的PTM布线电路。
Large‐scale characterization of post‐translational modifications (PTMs), such as phosphorylation, acetylation and ubiquitination, has highlighted their importance in the regulation of a myriad of signaling events. While high‐throughput technologies have tremendously helped cataloguing the proteins modified by these PTMs, the identification of lysine‐methylated proteins, a PTM involving the transfer of one, two or three methyl groups to the ε‐amine of a lysine side chain, has lagged behind. While the initial findings were focused on the methylation of histone proteins, several studies have recently identified novel non‐histone lysine‐methylated proteins. This review provides a compilation of all lysine methylation sites reported to date. We also present key examples showing the impact of lysine methylation and discuss the circuitries wired by this important PTM.
登录
查看更多内容
影响因子：
6.4
作者：
Barbier M;Owings JP;Martínez-Ramos I;Damron FH;Gomila R;Blázquez J;Goldberg JB;Albertí S
通讯作者：
Albertí S
影响因子：
3.2
作者：
Cameron, DM;Gregory, ST;Dahlberg, AE
通讯作者：
Dahlberg, AE
影响因子：
3.2
作者：
Abeykoon, Amila H.;Chao, Chien-Chung;Ching, Wei-Mei
通讯作者：
Ching, Wei-Mei
影响因子：
3.2
作者：
AMARO, AM;JEREZ, CA
通讯作者：
JEREZ, CA
影响因子：
4.1
作者：
BROWN, RH;RICHARDSON, M;BOULTER, D
通讯作者：
BOULTER, D