INTERMEDIATES AND BARRIER CROSSING IN A RANDOM ENERGY-MODEL (WITH APPLICATIONS TO PROTEIN FOLDING)
INTERMEDIATES AND BARRIER CROSSING IN A RANDOM ENERGY-MODEL (WITH APPLICATIONS TO PROTEIN FOLDING)
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DOI：
10.1021/j100356a007
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发表时间：
1989-09-21
影响因子：
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通讯作者：
WOLYNES, PG
中科院分区：
文献类型：
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作者：
BRYNGELSON, JD;WOLYNES, PG
我们通过一个简单的蛋白质折叠模型的应用，展示了如何随机哈密顿量可以用来研究一个复杂的化学反应。该模型被发现有许多亚稳态和这些状态的性质进行了研究。过渡态理论的一个简单的推广，并用于估计折叠时间的模型。发现它有一个玻璃相，那里的动力学非常缓慢。我们的研究结果的相关性蛋白质折叠和复杂的化学反应的一般问题进行了讨论。
We show, by application to a simple protein folding model, how a stochastic Hamiltonian can be used tostudy a complex chemical reaction. This model is found to have many metastable states and the properties of these states are investigated. A simple generalization of transition-state theory is developed and used toestimate the folding timefor the model. It is found to have a glass phase where thedynamics is very slow. The relevance of our results to protein folding and the general problem of complex chemical reactions is discussed.