REGIONAL ASSIGNMENT OF THE HUMAN LOCI FOR UVOMORULIN (UVO) AND CHYMOTRYPSINOGEN-B (CTRB) WITH THE HELP OF 2 OVERLAPPING DELETIONS ON THE LONG ARM OF CHROMOSOME-16
REGIONAL ASSIGNMENT OF THE HUMAN LOCI FOR UVOMORULIN (UVO) AND CHYMOTRYPSINOGEN-B (CTRB) WITH THE HELP OF 2 OVERLAPPING DELETIONS ON THE LONG ARM OF CHROMOSOME-16
复制标题
DOI：
10.1159/000132745
复制
发表时间：
1989-01-01
期刊：
影响因子：
--
通讯作者：
SCHERER, G
中科院分区：
文献类型：
--
作者：
NATT, E;MAGENIS, RE;SCHERER, G
Using cDNA probes for the human uvomorulin (UVO) and rat chymotrypsinogen B (CTRB) genes, we have analyzed two overlapping interstitial deletions on human chromosome 16q by Southern blot analysis. One deletion, with breakpoints at 16q22.1 and 16q22.3, results in loss of the UVO locus. The second deletion, whose breakpoints are at 16q22.1 and 16q23.2, leads to loss of the CTRB locus. Therefore, UVO residues between both proximal deletion breakpoints within band 16q22.1, whereas CTRB is located between both distal breakpoints at 16q22.3 and 16q23.2.
