The relationship among TAFI, t-PA, PAI-1 and F1+2 in type 2 diabetic patients with normoalbuminuria and microalbuminuria
The relationship among TAFI, t-PA, PAI-1 and F1+2 in type 2 diabetic patients with normoalbuminuria and microalbuminuria
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DOI：
10.1097/mbc.0b013e328346f8ca
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发表时间：
2011-09-01
影响因子：
1.1
通讯作者：
Kubisz, Peter
中科院分区：
文献类型：
--
作者：
Chudy, Peter;Kotulicova, Daniela;Kubisz, Peter
2型糖尿病（DM 2）患者凝血和纤溶功能紊乱导致大血管并发症（如心肌梗死和缺血性卒中）发生率增加。本研究旨在探讨纤溶酶原激活物抑制物1（派-1）、凝血酶激活的纤溶抑制物（TAFI）、组织型纤溶酶原激活物（t-PA）、凝血酶原片段1 + 2（F1 + 2）与血糖控制、高血压、性别及体重指数（BMI）的关系。正常白蛋白尿（NAU）组42例，微量白蛋白尿（MAU）组42例，正常对照组42例。采用酶联免疫吸附试验（ELISA）检测TAFI、派-1、t-PA和F1 + 2。与对照组相比，MAU组TAFI显著增加，两组派-1和F1 + 2均增加，两组t-PA均未升高。NAU：TAFI与纤维蛋白原（r=0.65，P=0.02）、派-1与甘油三酯（r=0.67，P=0.01）、MAU：TAFI与F1 + 2（r=0.48，P=0.02）、TAFI与收缩压（r=0.53，P=0.01）、派-1与BMI（r=0.43，P =0.01）呈正相关。
Disturbances of coagulation and fibrinolysis in type 2 diabetes mellitus (DM2) contribute to increased rates of macrovascular complications such as myocardial infarction and ischemic stroke. The aim of the study was to investigate the relationship among plasminogen activator inhibitor 1 (PAI-1), thrombin-activable fibrinolysis inhibitor (TAFI), tissue plasminogen activator (t-PA), prothrombin fragments 1 + 2 (F1 + 2), glycemic control, hypertension, sex and body mass index (BMI) in DM2 patients with normoalbuminuria and microalbuminuria. Forty-two normoalbuminuric (NAU), 42 microalbuminuric (MAU) patients with DM2 and 42 blood donors as control group were enrolled. TAFI, PAI-1, t-PA and F1 + 2 were assessed by enzyme-linked immunosorbent assay (ELISA) in all patients. TAFI was significantly increased in the MAU group, PAI-1 and F1 + 2 were increased in both groups and t-PA was not elevated in either group compared to controls. We found positive correlations in the NAU: TAFI and fibrinogen (r=0.65, P=0.02), PAI-1 and triglycerides (r=0.67, P=0.01), in the MAU: TAFI and F1 + 2 (r=0.48, P=0.02), TAFI and systolic blood pressure (r=0.53, P=0.01), PAI-1 and BMI (r=0.43, P