Accurate measurement of stable isotopes of lithium by inductively coupled plasma mass spectrometry.
Accurate measurement of stable isotopes of lithium by inductively coupled plasma mass spectrometry.
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通过电感耦合等离子体质谱法准确测量锂的稳定同位素。
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
M. Janghorbani
中科院分区：
文献类型：
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作者：
X. F. Sun;B. Ting;S. Zeisel;M. Janghorbani
报道了一种基于电感耦合等离子体质谱（ICP-MS）的人血和尿中锂同位素的精确分析方法。该方法允许精确和准确地测量6Li/7 Li的同位素比，对于接受锂治疗的患者的尿液和血液中典型的锂浓度范围，其在±1%（RSD）内。测量的同位素比是独立的离子束强度的典型漂移。仪器对增加的同位素比的响应在自然比率以上至少一个数量级是高度线性的。该方法测量精度为1%（RSD），每次测量时间小于7 min，采用6Li体外稀释法，对单个样品的总精度优于3%，12次测量的平均偏差优于1%。
A method based on inductively coupled plasma mass spectrometry (ICP-MS), for accurate isotopic analysis of lithium in human blood and urine is reported. The method permits the precise and accurate measurement of isotope ratios for 6Li/7Li to within ±1%(RSD) for the lithium concentration range typical of urine and blood from patients on lithium therapy. The measured isotope ratio is independent of typical drifts in the ion beam intensities. The instrument response to increasing isotope ratio is highly linear for at least an order of magnitude above the natural ratio. Complete isotope ratio data acquisition for a measurement precision of 1%(RSD) can be carried out in less than 7 min per sample.Applying the method of in vitro isotope dilution with 6Li as the spike, the over-all accuracy of the method is better than 3% for any single sample, with a mean deviation in 12 measurements of better than 1%.