Preclinical development of SMA artificial anal sphincters
Preclinical development of SMA artificial anal sphincters
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DOI：
10.1080/13645700600836695
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发表时间：
2006-01
影响因子：
1.7
通讯作者：
Yun Luo;M. Higa;S. Amae;T. Takagi;T. Yambe;Takeshi Okuyama;Hiromu Tanaka;Y. Kakubari;H. Matsuki-H
中科院分区：
文献类型：
--
作者：
Yun Luo;M. Higa;S. Amae;T. Takagi;T. Yambe;Takeshi Okuyama;Hiromu Tanaka;Y. Kakubari;H. Matsuki-H
本文介绍了形状记忆合金人工肛门括约肌临床前试验的一些进展。这种新型装置是由东北大学的作者小组提出并开发的。它有两个不同于其他系统的主要特征，这些系统要么是临床可用的，要么仍在开发中。一种是采用形状记忆合金（SMA）带和具有层状结构的硅橡胶弹性体片的组合的固体驱动元件来实现人工括约肌的打开和关闭功能。另一种是用于闭合肠的夹层机制，以减少屈曲引起的缺血的风险，其已在具有径向挤压机制的液压驱动人工括约肌中报道。该装置在体内的部件较少，因此更容易植入。新的设计消除了热灼伤的风险，使其能够长期植入，并使该设备更接近实际使用。该器械的功能性和安全性已在三个月的动物实验中得到证明。
This article presents some progress in the development for preclinical trials of an artificial anal sphincter using shape memory alloys. The novel device has been proposed and developed by the author's group at Tohoku University. It has two dominant features different from other systems, which are either clinically available or still under development. One is that a solid driving element, a combination of shape memory alloy (SMA) ribbons and silicone elastomer sheets with a layered structure, is adopted for the opening and closing functions of the artificial sphincter. The other is a sandwich mechanism for the closing of bowel to reduce the risk of buckling induced ischemia which has been reported in hydraulically driven artificial sphincters with a radial squeezing mechanism. The device has fewer parts inside the body and therefore be implanted more easily. A new design eliminating the risk of heat burns enables long‐term implantation and brings the device closer to practical use. Functionality and safety of the device have been proved in three‐month animal experiments.