Differences in salivary cortisol levels in cocaine-exposed and noncocaine-exposed NICU infants.
Differences in salivary cortisol levels in cocaine-exposed and noncocaine-exposed NICU infants.
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接触可卡因和非接触可卡因的 NICU 婴儿唾液皮质醇水平的差异。
DOI：
10.1002/dev.420250203
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发表时间：
1992
影响因子：
2.2
通讯作者：
Karmel,BZ
中科院分区：
文献类型：
--
作者：
Magnano,CL;Gardner,JM;Karmel,BZ
为了评估宫内可卡因暴露是否影响新生儿期肾上腺皮质的反应性，在出院前比较了非可卡因暴露组(n=35)和可卡因暴露组(n=11)健康早产儿的唾液皮质醇水平。皮质醇水平在三种情况下测量：基础--无干扰事件或行为困扰后120min；非侵入性应激源--神经行为检查后30min；侵入性应激源--脚跟棒手术后30min。非可卡因暴露组和可卡因暴露组婴儿的基础皮质醇水平没有差异，但可卡因暴露组婴儿在非侵入性和侵袭性应激源条件下的基础皮质醇水平都明显较低。暴露在可卡因中的婴儿对应激事件的皮质醇反应受到抑制，这表明这些婴儿对正常应激事件的调制能力可能降低，这可能是报告的一些微妙的状态调节问题的基础。©1992威利父子公司。Inc.
To assess whether cocaine exposure in utero affected adrenocortical responsiveness in the neonatal period, salivary cortisol levels were compared between noncocaine‐exposed (n= 35) and cocaine‐exposed (n= 11) healthy preterm infants just prior to hospital discharge. Cortisol levels were measured under three conditions: Basal—120 min after no disrupting event or behavioral distress; Noninvasive Stressor—30 min after a neurobehavioral examination; Invasive Stressor—30 min after a heel‐stick procedure. There were no differences in Basal cortisol levels between the noncocaine‐exposed and cocaine‐exposed infants, but the cocaine‐exposed infants had significantly lower levels in both the Noninvasive and Invasive Stressor conditions. The suppressed cortisol responding to stressful events in cocaine‐exposed infants suggests that these infants may have decreased modulation capability to normally stressful events, which could underlie some of the subtle state regulation problems reported. © 1992 Wiley & sons. Inc.