Nanostructure, effective properties, and deformation pattern of the cochlear outer hair cell cytoskeleton.
Nanostructure, effective properties, and deformation pattern of the cochlear outer hair cell cytoskeleton.
复制标题
耳蜗外毛细胞骨架的纳米结构、有效特性和变形模式。
DOI：
10.1115/1.1448521
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Popel,AleksanderS
中科院分区：
文献类型：
--
作者：
Spector,AlexanderA;Ameen,Mohammed;Charalambides,PanosG;Popel,AleksanderS
We consider the mechanical properties of the outer hair cell cytoskeleton. The cytoskeleton is represented as a set of microdomains of different sizes and orientations composed of actin filaments and spectrin crosslinks. An intermediate material between domains is also introduced. The domain characteristics are randomly generated and the histograms of the cytoskeleton stiffness moduli are obtained. We solve an inverse problem and estimate the stiffness of the crosslink and connective molecule in the intermediate material. We discovered a pattern of highly inhomogeneous deformation of the cytoskeleton where the circumferential strain is primarily determined by the deformation of the intermediate material.
